Question 1

Which of the following types of alterations would NOT promote tumorigenesis?

Accepted Answer

A)  Overexpression of MDM2
B)  Overexpression of Bak
C)  Overexpression of Bcl-2
D)  Defective Chk2 kinase signaling
E)  Increased activation of PI3KF) C) and D)
G) B) and E) B

Question 2

The cell's latent suicide program,resulting in rapid cell death,is called

Accepted Answer

A)  Apoptosis.
B)  Necrosis.
C)  Eradication.
D)  Ischemia.
E)  Caspase.F) A) and B)
G) None of the above

Question 3

DNA damage may result in all of the following EXCEPT

Accepted Answer

A)  Increased activation of ATM.
B)  Increased activation of Chk1/Chk2.
C)  Increased levels of p53 protein.
D)  DNA double strand breaks.
E)  Ubiquitylation of p53.F) C) and D)
G) A) and D) E

Question 4

Increased expression of MDM2 may result in

Accepted Answer

A)  Increased expression of p53.
B)  Apoptosis.
C)  Cell cycle arrest.
D)  Degradation of p53.
E)  Senescence.F) B) and E)
G) A) and B)

Question 5

An irreversible arrest in the cell cycle resulting in a viable but nongrowing state is known as

Accepted Answer

A)  The arrest point.
B)  Senescence.
C)  Quiescence.
D)  Inactivation.
E)  Involution.F) C) and D)
G) A) and C)

Question 6

p53 signaling may result in all of the following EXCEPT

Accepted Answer

A)  Apoptosis.
B)  Senescence.
C)  Angiogenesis.
D)  DNA repair.
E)  Cytostatic response.F) All of the above
G) None of the above

Question 7

Release of cytochrome c from the mitochondrial membrane is stimulated by

Accepted Answer

A)  Bcl-2 and Bcl-XL.
B)  Bax and Bad.
C)  Bcl-W and Mcl-1.
D)  Caspase-9.
E)  None of the above.F) None of the above
G) A) and E)

Question 8

The process of formation of new blood vessels is called

Accepted Answer

A)  Leukemogenesis.
B)  Hematopoiesis.
C)  Vasculogenesis.
D)  Thrombopoiesis.
E)  Angiogenesis.F) C) and E)
G) C) and D)

Question 9

The p14ARF protein may be activated in response to all of the following EXCEPT

Accepted Answer

A)  Ras signaling.
B)  Increased levels of E1A.
C)  Decreased activity of E2F transcription factors.
D)  C-Myc signaling.
E)  None of the above.F) None of the above
G) B) and D)

Question 10

Which of the following proteins may INHIBIT apoptosis?

Accepted Answer

A)  Bcl-2
B)  Caspase-9
C)  Lamin
D)  Apaf-1
E)  NoxaF) B) and C)
G) C) and E)

Question 11

Which of the following proteins has a BH4 domain?

Accepted Answer

A)  Bax
B)  Bid
C)  Puma
D)  Bcl-2
E)  HrkF) C) and E)
G) A) and B)

Question 12

Which of the following is NOT true of p53?

Accepted Answer

A)  Most tumor-associated p53 mutations are the result of nonsense codons.
B)  p53 is mutated in over 30-50% of all cancers.
C)  Normal p53 functions as a "tumor suppressor."
D)  Mice lacking p53 are viable.
E)  Exposure to UV radiation results in increased expression of p53.F) B) and D)
G) A) and C)

Question 13

Which of the following results in an increase in the levels of p53 protein?

Accepted Answer

A)  Oncogenic signaling
B)  UV radiation
C)  Ionizing radiation
D)  Hypoxia
E)  All of the aboveF) B) and E)
G) A) and E) E

Question 14

Which of the following scenarios will NOT result in an increase in apoptotic activity?

Accepted Answer

A)  Overexpression of Noxa
B)  Inhibition of Bcl-2 signaling
C)  Phosphorylation of Bim
D)  Activation of caspase-9
E)  Flux in cellular calcium levelsF) A) and E)
G) C) and D)

Question 15

Which of the following types of p53 mutations would be MOST beneficial to a tumor cell?

Accepted Answer

A)  Splice site change.
B)  Premature stop codon.
C)  Silent mutation.
D)  Frameshift.
E)  Missense mutation.F) A) and B)
G) C) and E)

Question 16

Apoptotic cell death can be induced by

Accepted Answer

A)  p53 signaling.
B)  Signaling from surface cell death receptors.
C)  Extracellular stresses.
D)  A,B,and C.
E)  None of the above.F) A) and B)
G) C) and D)

Exam 9: P53 and Apoptosis: Master Guardian and Executioner

Which of the following types of alterations would NOT promote tumorigenesis?

Correct Answer
verified
B

The cell's latent suicide program,resulting in rapid cell death,is called

Correct Answer
verified

DNA damage may result in all of the following EXCEPT

Correct Answer
verified
E

Increased expression of MDM2 may result in

Correct Answer
verified

An irreversible arrest in the cell cycle resulting in a viable but nongrowing state is known as

Correct Answer
verified

p53 signaling may result in all of the following EXCEPT

Correct Answer
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Release of cytochrome c from the mitochondrial membrane is stimulated by

Correct Answer
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The process of formation of new blood vessels is called

Correct Answer
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The p14^ARF protein may be activated in response to all of the following EXCEPT

Correct Answer
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Which of the following proteins may INHIBIT apoptosis?

Correct Answer
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Which of the following proteins has a BH4 domain?

Correct Answer
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Which of the following is NOT true of p53?

Correct Answer
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Which of the following results in an increase in the levels of p53 protein?

Correct Answer
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E

Which of the following scenarios will NOT result in an increase in apoptotic activity?

Correct Answer
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Which of the following types of p53 mutations would be MOST beneficial to a tumor cell?

Correct Answer
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Apoptotic cell death can be induced by

Correct Answer
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Exam 9: P53 and Apoptosis: Master Guardian and Executioner

Which of the following types of alterations would NOT promote tumorigenesis?

Correct AnswerverifiedB

The cell's latent suicide program,resulting in rapid cell death,is called

Correct AnswerverifiedShow Answer

DNA damage may result in all of the following EXCEPT

Correct AnswerverifiedE

Increased expression of MDM2 may result in

Correct AnswerverifiedShow Answer

An irreversible arrest in the cell cycle resulting in a viable but nongrowing state is known as

Correct AnswerverifiedShow Answer

p53 signaling may result in all of the following EXCEPT

Correct AnswerverifiedShow Answer

Release of cytochrome c from the mitochondrial membrane is stimulated by

Correct AnswerverifiedShow Answer

The process of formation of new blood vessels is called

Correct AnswerverifiedShow Answer

The p14ARF protein may be activated in response to all of the following EXCEPT

Correct AnswerverifiedShow Answer

Which of the following proteins may INHIBIT apoptosis?

Correct AnswerverifiedShow Answer

Which of the following proteins has a BH4 domain?

Correct AnswerverifiedShow Answer

Which of the following is NOT true of p53?

Correct AnswerverifiedShow Answer

Which of the following results in an increase in the levels of p53 protein?

Correct AnswerverifiedE

Which of the following scenarios will NOT result in an increase in apoptotic activity?

Correct AnswerverifiedShow Answer

Which of the following types of p53 mutations would be MOST beneficial to a tumor cell?

Correct AnswerverifiedShow Answer

Apoptotic cell death can be induced by

Correct AnswerverifiedShow Answer

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B

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E

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The p14^ARF protein may be activated in response to all of the following EXCEPT

Correct Answer
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E

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