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In eukaryotes,translation takes place


A) on the plasma membrane.
B) inside the nucleus.
C) on ribosomes.
D) on the nuclear membrane.
E) on spliceosomes.

F) A) and C)
G) A) and B)

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Which molecule combines with proteins to form both the large and small ribosomal subunits?


A) DNA
B) RNA polymerase
C) miRNA
D) rRNA
E) tRNA

F) B) and E)
G) All of the above

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Codons that serve as "stop" signals for translation are recognized by


A) tRNA.
B) release factors.
C) anticodons.
D) translation terminators.
E) aminoacyl-tRNA synthetases

F) B) and D)
G) A) and B)

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Analysis of a bacterial gene indicates that 24% of the nucleotides in the coding strand contain the base A,18% contain the base T,26% contain the base G,and 32% contain the base C.What percent of the nucleotides in the mRNA transcribed from this gene will contain the base U? (Enter your answer as a number only without the percent sign,e.g.enter 5 not 5%.)

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To remove noncoding sequences in the pre-mRNA of eukaryotes,multiple snRNPs combine with proteins to form a larger complex called the ________.


A) 5' cap
B) introsome
C) ribosome
D) spliceosome
E) 3' poly-A tail

F) D) and E)
G) C) and D)

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The "one-gene/one-enzyme" hypothesis was proposed by


A) Watson and Crick.
B) Griffith.
C) Garrod.
D) Franklin.
E) Beadle and Tatum.

F) D) and E)
G) A) and E)

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In prokaryotes,the form of RNA polymerase that can accurately initiate synthesis of RNA is called


A) the holoenzyme.
B) the core polymerase.
C) RNA polymerase II.
D) RNA polymerase III.
E) the sigma subunit.

F) C) and D)
G) C) and E)

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The sequence of nucleotides in a DNA molecule is called the ________ code.


A) protein
B) ribosomal
C) translation
D) genetic
E) amino acid

F) A) and E)
G) B) and C)

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During translation,amino acids are carried to the ribosome by


A) mRNA.
B) tRNA.
C) snRNA.
D) rRNA.
E) miRNA.

F) A) and B)
G) A) and E)

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Ribosomes are complex aggregates of


A) RNA and DNA.
B) RNA and proteins.
C) RNA and sugars.
D) DNA and proteins.
E) nucleosomes and RNA.

F) B) and C)
G) All of the above

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Eukaryotic and prokaryotic organisms differ in how they process genetic information.Which statements best explain one of these differences?


A) In prokaryotes,translation of the mRNA begins before transcription is complete.In eukaryotes,transcription and modification of the mRNA is completed before translation begins.
B) In prokaryotes,genes are transcribed directly into polypeptides.In eukaryotes,genes are transcribed into RNA which is used to assemble polypeptides.
C) In prokaryotes,translation occurs before genes are transcribed into mRNA.In eukaryotes,genes are transcribed into mRNA which is then translated into polypeptides.
D) In prokaryotes,introns are removed before genes are transcribed into mRNA.In eukaryotes,introns are removed after genes are transcribed into mRNA.

E) All of the above
F) None of the above

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Gene expression involves two phases,________ and translation.


A) replication
B) transcription
C) initiation
D) condensation

E) A) and D)
F) All of the above

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The mutation responsible for Huntington's disease is a


A) missense mutation.
B) nonsense mutation.
C) frameshift mutation.
D) triplet repeat expansion mutation.

E) A) and C)
F) A) and B)

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When a polypeptide is being assembled,the bond that forms between a newly added amino acid and the previous amino acid in the chain is a ________ bond.


A) hydrogen
B) hydrophobic
C) terminal
D) phosphodiester
E) peptide

F) C) and E)
G) B) and E)

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You are excited because your lab is studying the first microorganisms retrieved from Mars! Interestingly,their genetic material consists of a single-stranded nucleic acid with six different nitrogenous bases.Like organisms from Earth,segments of the nucleic acid contain the code for making proteins.If the genetic code in these organisms was read in groups of 2 bases instead of 3,what is the maximum number of amino acids that could be coded for assuming that only one codon functioned as a stop codon? (Enter your answer as a numeral not a word,e.g.enter 17 not seventeen.)

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You are studying an individual with very low levels of insulin in her blood.Further analysis indicates that cells of her pancreas are producing normal levels of this protein,but it is accumulating in the cytoplasm rather than being secreted from the cells.Which hypothesis makes the most sense to explain this observation?


A) A small deletion has removed the nucleotides that code for the signal sequence at the amino terminus of the protein.
B) A missense mutation has caused premature termination during translation of this protein.
C) A chromosomal segment that includes the gene for insulin has been inverted.
D) A two-base deletion near the middle of the gene has altered the reading frame during translation of the protein.
E) A missense mutation has altered the ribosome-binding sequence at the 5' end of the mRNA.

F) B) and D)
G) A) and B)

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Which base in an anticodon will pair with the base adenine in a codon?


A) thymine
B) cytosine
C) guanine
D) uracil

E) None of the above
F) A) and B)

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During translation in prokaryotes,formation of the initiation complex requires all of the following except


A) a small ribosomal subunit.
B) mRNA.
C) tRNA charged with N-formylmethionine.
D) RNA polymerase.
E) initiation factors.

F) A) and E)
G) C) and D)

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During ________,RNA polymerase synthesizes a molecule of RNA using DNA as a template.


A) mRNA splicing
B) translation
C) transcription
D) gene sequencing
E) termination

F) B) and E)
G) A) and B)

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