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In DNA,complementary nitrogen bases are held together by


A) nitrogen bonds.
B) hydrogen bonds.
C) hydrophobic bonds.
D) peptide bonds.
E) phosphodiester bonds.

F) A) and B)
G) B) and E)

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In 1952,Hershey and Chase confirmed Avery's (1944) conclusion that


A) proteins are the repositories for hereditary information.
B) DNA is the repository for hereditary information.
C) RNA is the repository for hereditary information.
D) each DNA molecule is composed of two strands that are twisted into a double helix.
E) the replication of DNA is semiconservative.

F) A) and B)
G) B) and E)

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You are asked to participate in a clinical trial for a new drug that can activate telomerase.Which of the following is a likely risk of such a drug?


A) decreased capacity for tissue repair
B) increased vulnerability to cancer
C) premature aging
D) decreased telomere length

E) None of the above
F) A) and B)

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Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder.Patients with XP exhibit a cellular hypersensitivity to ultraviolet (UV) radiation,a high incidence of skin cancer and premature aging.Based on these clinical characteristics,what is the most likely cause for this disease?


A) defects in DNA repair
B) defects in DNA replication
C) lack of telomerase activity
D) shortened telomeres

E) A) and D)
F) B) and C)

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A

________ is the genetic material for all cellular organisms and some viruses.


A) RNA
B) DNA
C) Protein
D) Chromatin

E) C) and D)
F) A) and C)

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After DNA replication is complete,each strand of the original molecule is bound to a new complementary strand.This process is known as


A) disruptive replication.
B) conservative replication.
C) semiconservative replication.
D) dispersive replication.
E) stabilizing replication.

F) All of the above
G) C) and E)

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Eukaryotic organisms speed up the process of DNA replication by


A) shortening the initiation phase.
B) producing several sliding clamp complexes which provide more binding sites for DNA pol III.
C) using DNA gyrase to unravel the double helix rather than DNA helicase.
D) using multiple origins of replication on each chromosome.

E) A) and B)
F) A) and C)

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Watson and Crick developed a model of DNA in which the two strands twist into the shape of a ________.


A) circle
B) helix
C) double helix
D) double pleated sheet

E) B) and D)
F) A) and C)

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C

Information obtained by Franklin from X-ray crystallography on DNA suggested that it is shaped like a


A) helix.
B) ribbon.
C) hollow cylinder.
D) pleated sheet.
E) icosahedron.

F) B) and E)
G) D) and E)

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The ends of linear chromosomes that maintain chromosome integrity are called


A) telomeres
B) the replisome
C) thymine dimers
D) kinetochores
E) kinetin

F) B) and E)
G) C) and D)

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Deoxyribose has a carbon atom that is not part of the pentose ring.In a nucleotide,what is attached to this carbon?


A) a nitrogenous base
B) a phosphate group
C) three hydrogen atoms
D) one hydrogen atom

E) A) and D)
F) A) and C)

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B

The method of DNA replication,where each original strand is used as a template to build a new strand,is called the


A) conservative method.
B) semiconservative method.
C) disruptive method.
D) continuous method.
E) replication and amplification method.

F) All of the above
G) A) and E)

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The replisome has two main subcomponents.They are


A) the replication folk and the sliding clamp subunit.
B) the primosome and the sliding clamp subunit.
C) the replication folk and the DNA pol III enzymes.
D) the DNA pol III enzymes and the sliding clamp subunits.
E) the primosome and the DNA pol III enzymes.

F) C) and D)
G) A) and C)

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If a mutation prevented synthesis of the beta subunit of DNA pol III,which would be most affected?


A) DNA unwinding
B) formation of RNA primers
C) formation of the replication fork
D) processivity
E) removal of RNA primers

F) C) and D)
G) All of the above

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If a short sequence of DNA is 5' AATTGCCGT 3',its complement is


A) 5' AAAACGCCA 3'.
B) 3' TTAACGGCT 5'.
C) 3' TTAACGGCA 5'.
D) 3' TTAAGCCGA 5'.
E) 5' TTAACGGCA 3'.

F) A) and B)
G) A) and C)

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Who proposed that in any DNA molecule,A = T and G = C?


A) Hershey and Chase
B) Chargaff
C) Franklin
D) Watson and Crick

E) A) and B)
F) A) and C)

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Which of the following DNA sequences is complementary to 5' ATGGTCAGT 3'?


A) 5' ATGGTCAGT 3'
B) 5' TGACTGGTA 3'
C) 5' TACCAGTCA 3'
D) 5' ACTGACCAT 3'

E) A) and B)
F) All of the above

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Based on their experiment with T2 bacteriophages,Hershey and Chase concluded that


A) DNA replication is semiconservative.
B) the phage coat contains the genetic material.
C) DNA functions as the genetic material.
D) A always pairs with T and G always pairs with C.
E) virulent bacteria can transform nonvirulent bacteria.

F) D) and E)
G) A) and B)

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I think the proactive stance is a better attitude to promote than after-the-fact worrying! When planning a long week of sunbathing on the beach,What type of DNA damage should sunbathers be aware of before hitting the beach?


A) photolyase-induced mutations
B) decreased telomere length
C) thymine dimers
D) activation of uvr A,B,and C genes

E) B) and D)
F) C) and D)

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You are asked to give a classroom demonstration of DNA supercoiling.To do so,you take two different colored pieces of rubber tubing,twist them very tightly and excessively around each other and join the ends of the tubing appropriately.Next,you relieve the supercoiling by breaking one strand and unwinding it.In this demonstration,the breaking and unwinding to relieve the supercoiling simulates the action of


A) exonucleases.
B) polymerases.
C) ligases.
D) topoisomerases.
E) primases.

F) A) and B)
G) A) and E)

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