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Many of the antiviral drugs currently used to treat HIV/AIDS also interfere with an enzyme that helps mitochondria multiply.Treatment can therefore result in a decrease in the number of mitochondria found in certain tissues.Given this information,what might you expect to see in patients treated with antiviral drugs?


A) An increase in oxidative phosphorylation
B) An increase in phosphofructokinase activity
C) An increase in NADH dehydrogenase activity
D) An increase in lactic acid levels

E) A) and C)
F) A) and B)

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One way to generate acetyl-CoA is to convert pyruvate into acetyl-CoA by stripping off a CO2 molecule.The removal of CO2 is referred to as what type of reaction?


A) Decarboxylation
B) Glycolytic
C) Carboxylation
D) Acetylation

E) B) and D)
F) B) and C)

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What oxidizing agent is used to temporarily store high energy electrons harvested from glucose molecules in a series of gradual steps in the cytoplasm?


A) FADH2
B) ADP
C) NAD+
D) Oxygen

E) A) and D)
F) C) and D)

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Organisms that depend on the energy stored in chemical bonds by other organisms for their food energy are called ________.


A) Autotrophs
B) Heterotrophs
C) Oligotrophs
D) Chemotrophs

E) A) and B)
F) A) and C)

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The Citric acid cycle occurs in the mitochondria.There are nine biochemical reactions involved in the Citric acid cycle,and they are highly ordered.Select the correct order.(Note: These are abbreviated and do not show NAD,ADP,ATP,or FAD.)


A) acetyl-CoA joins the Citric acid cycle and unites with oxaloacetate →forming citrate →which forms beta-ketoglutarate → which forms succinyl-CoA → which forms succinate → which forms fumarate → which forms malate → which forms oxaloacetate
B) acetyl-CoA joins the Citric acid cycle and unites with oxaloacetate →forming citrate →which forms alpha-ketoglutarate → which forms succinyl-CoA → which forms succinate → which forms malate → which forms fumarate → which forms oxaloacetate
C) acetyl-CoA joins the Citric acid cycle and unites with oxaloacetate →which forms alpha-ketoglutarate → forming citrate → which forms succinyl-CoA → which forms succinate → which forms fumarate → which forms malate → which forms oxaloacetate
D) acetyl-CoA joins the Citric acid cycle and unites with oxaloacetate →forming citrate →which forms alpha-ketoglutarate → which forms succinyl-CoA → which forms succinate → which forms fumarate → which forms malate → which forms oxaloacetate

E) A) and B)
F) C) and D)

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What important metabolic intermediate does not cross the inner membrane of the mitochondria?


A) ATP
B) Acetyl-CoA
C) Pyruvate
D) Oxygen

E) C) and D)
F) A) and B)

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Regardless of the electron or hydrogen acceptor used,one of the products of fermentation is always


A) ADP.
B) ATP.
C) NAD+.
D) pyruvate.
E) alcohol.

F) B) and E)
G) A) and B)

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To form NADH from NAD+,two electrons and a proton are removed from an organic molecule.What term best describes the reaction in which electrons and a proton are removed from an organic molecule?


A) Condensation
B) Reduction
C) Dehydrogenation
D) Decarboxylation
E) Isomerization

F) A) and E)
G) A) and D)

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During what step of glycolysis are two ATP molecules required?


A) Cleavage and rearrangement
B) Glucose priming
C) Oxidation
D) Pyruvate formation
E) Acetyl-CoA formation

F) None of the above
G) C) and D)

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In the reaction: C4H6O4 + FAD →C4H4O4 + FADH2,what type of reaction took place to remove the protons from C4H6O4?


A) Decarboxylation
B) Reduction
C) Dehydrogenation
D) Oxidation

E) B) and D)
F) All of the above

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What are the products of one turn of the Citric acid cycle?


A) 1 CO2,2 NADH,1 FADH2,1 ATP
B) 2 CO2,3 NADH,1 FADH2,1 ATP
C) 2 CO2,6 NADH,2 FADH2,2 ATP
D) 4 CO2,6 NADH,2 FADH2,2 ATP
E) 4 CO2,12 NADH,4 FADH2,4 ATP

F) None of the above
G) A) and B)

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How many oxidation reactions occur during the Citric acid cycle?


A) 1
B) 2
C) 4
D) 6
E) 9

F) D) and E)
G) A) and D)

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In glycolysis,a major portion of the energy remains in the final product,which is called


A) glucose.
B) citrate.
C) glyceraldehyde 3-phosphate (G3P) .
D) pyruvate.

E) B) and C)
F) A) and B)

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What would be the ATP yield for a molecule that is catabolized to form one molecule of pyruvate in a eukaryotic cell?


A) 10 ATP
B) 12.5 ATP
C) 25 ATP
D) 30 ATP
E) 11.5 ATP

F) A) and E)
G) A) and D)

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When substrate-level phosphorylation occurs,it means that:


A) NAD+ is converted into NADH.
B) ATP is converted into ADP plus a phosphate group.
C) ADP is converted into ATP by the addition of a phosphate group.
D) NADH is converted into NAD+ plus a proton.

E) A) and B)
F) All of the above

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What is common to all of the oxidation reactions in the Citric acid cycle?


A) They all lead to the generation of NADH.
B) They are all decarboxylation reactions.
C) They are all characterized by a loss of electrons from an organic molecule coupled to the reduction of an electron acceptor.
D) They all lead to substrate-level phosphorylation of ADP to generate ATP.

E) A) and B)
F) B) and C)

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If citrate levels are high in the cell,but ATP levels are low,what do you think will happen in the cell?


A) In the presence of glucose,glycolysis will run to generate energy for the cell,but the Citric acid cycle will be inhibited.
B) Glycolysis will be inhibited,but the Citric acid cycle will be functional,allowing it to be utilized to break down acetyl-CoA generated from beta-oxidation.
C) The electron transport chain will be inhibited,causing a build-up of NADH and FADH2.This will inhibit the Citric acid cycle,but in the presence of glucose,glycolysis will still run coupled with fermentation to regenerate NAD+.
D) Glycolysis and the Citric acid cycle will both be inhibited,thus under these conditions there will be no mechanism to generate ATP.

E) A) and B)
F) A) and C)

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Cytochromes contain a heme group similar to that in hemoglobin.The iron atom (Fe) in the center of the group can be oxidized and reduced.If someone was suffering from iron deficiency anemia,what stage of cellular respiration would be most affected?


A) Glycolysis
B) The Citric acid cycle
C) The electron transport chain
D) Fermentation

E) A) and B)
F) A) and C)

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In the reaction catalyzed by aconitase,the conversion of citrate to isocitrate is inhibited by fluoroacetate.Fluoroacetate is used as a pesticide.Why is this an effective pesticide?


A) It inhibits glycolysis
B) It inhibits pyruvate oxidation
C) It inhibits the Citric acid cycle
D) It inhibits the electron transport chain
E) It inhibits ATP synthase

F) B) and E)
G) A) and E)

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