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Explain how the trp operon is regulated in a prokaryotic cell when tryptophan is present.

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A form of gene regulation that occurs while RNA is still in the nucleus is


A) differential intron removal and exon splicing.
B) feedback control.
C) enzymatic cleavage of a polypeptide.
D) rate of binding to ribosomes.

E) None of the above
F) A) and B)

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In the transcription of DNA,remodeling proteins push the histone portion of the nucleosome aside so that transcription may begin.

A) True
B) False

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The genes of a single operon are all regulated by the same repressor,operator,and promoter.

A) True
B) False

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Compared to just a century ago,a much larger percentage of the population is living to be 80-90 years old.Why does cancer seem to be a much larger problem today than a century ago?

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Identify which of the operon elements plays the most critical role in determining gene regulation in prokaryotes.

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The most critical level of eukaryotic genetic control is ________ control.


A) feedback
B) translational
C) transcriptional
D) posttranscriptional
E) posttranslational

F) B) and E)
G) C) and D)

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Active genes in eukaryotic cells are associated with


A) euchromatin.
B) heterochromatin.
C) methylated RNA and histones.
D) DNA with many methyl groups.

E) None of the above
F) B) and D)

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Point mutations


A) are due to a change in one DNA nucleotide.
B) may change a specific codon.
C) can cause a genetic disease such as sickle-cell disease that is due to a base change that codes for valine rather than glutamate.
D) All of the choices are correct.

E) A) and B)
F) A) and C)

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When a bacterium is introduced to a new environment with plenty of nutritional resources,binary fission will allow for rapid growth of the population (2-4-8-16-32-64 ...etc.) .However,there is usually a slight lag before the rapid growth begins.What is the best explanation for this lag period?


A) It takes time for bacterial cells to duplicate enough organelles to digest new media.
B) It takes time to induce and amplify the production of the enzymes needed for binary fission.
C) Binary fission becomes more and more efficient after each cell division.
D) The new media contains compounds that turn on repressor proteins.
E) Structural genes act more slowly than metabolic genes.

F) C) and E)
G) B) and E)

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The level of genetic control that involves the life span of the mRNA molecule and the ability of the mRNA to bind to ribosomes is ________ control.


A) feedback
B) translational
C) transcriptional
D) posttranscriptional
E) posttranslational

F) A) and C)
G) C) and D)

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An oncogene is


A) a viral gene with no relation to the host cell's genes.
B) a mutated form of a proto-oncogene.
C) a bacterial gene that causes cancer in the host.
D) always seen in human cancer cells.
E) a gene that turns off cellular reproduction.

F) B) and D)
G) A) and C)

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A deletion of one base pair that alters the sequence of codons is called a(n)


A) transposon.
B) substitution mutation.
C) carcinogen.
D) oncogene.
E) frameshift mutation.

F) A) and B)
G) C) and D)

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________ occurs as ________ builds up in the system if Enzyme A is nonfunctional because of an inherited mutation. AEABEBC (phenylalanine)   (tyrosine)   (melanin)  \begin{array} { l }A&E_A&B&E_B&C\\\text { (phenylalanine) }&\longrightarrow&\text { (tyrosine) }&\longrightarrow&\text { (melanin) }\end{array}


A) albinism; melanin
B) xeroderma pigmentosum; tyrosine
C) phenylketonuria; phenyalanine
D) androgen insensitivity; tyrosine

E) A) and D)
F) None of the above

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If CAP is absent from a cell,what are the potential consequences?


A) The individual cannot activate the catabolism of various other metabolites in the absence of glucose.
B) The individual does not have a backup system for survival when glucose is absent.
C) The individual will not be able to metabolize enough energy if glucose is absent.
D) All of these are consequences of the absence of CAP.

E) None of the above
F) A) and B)

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The level of genetic control that involves the processing of early RNA transcripts to mRNA and the rate at which mRNA leaves the nucleus is


A) feedback control.
B) translational control.
C) transcriptional control.
D) posttranscriptional control.
E) posttranslational control.

F) A) and D)
G) A) and B)

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You are more likely to develop some form of cancer if you


A) are exposed to higher doses of radiation including X-rays.
B) are exposed to carcinogens.
C) have a high incidence of cancer in your family history.
D) All of the choices are correct.

E) A) and B)
F) All of the above

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Which of the following series of events is associated with the formation of cancer?


A) The proto-oncogenes mutate and become oncogenes which are continuously active.There is also an associated loss of tumor suppressor gene activity allowing uncontrolled growth of cells.
B) The oncogenes mutate and become proto-oncogenes which are continuously active.There is also an associated loss of tumor suppressor gene activity allowing uncontrolled growth of cells.
C) The proto-oncogenes mutate and become oncogenes which stop functioning altogether.There is also an associated increase in the tumor suppressor gene activity allowing uncontrolled growth of cells.
D) The oncogenes mutate and become proto-oncogenes which stop functioning altogether.There is also an associated increase in the tumor suppressor gene activity allowing uncontrolled growth of cells.

E) B) and D)
F) B) and C)

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A Barr body


A) exists within the cell in the form of euchromatin.
B) is an inactive Y chromosome that produces reduced amount of gene products.
C) is an inactive X chromosome that does not produce gene products.
D) exists within the cell in the form of heterochromatin.
E) Two of the above answers are correct.

F) B) and E)
G) A) and E)

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Transposons


A) are specific DNA sequences that move within and between chromosomes.
B) alter the expression of neighboring genes especially if the transposon is a regulator gene.
C) have been discovered in corn,fruit flies,bacteria,and humans.
D) All of the choices are correct.

E) All of the above
F) A) and B)

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