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Exudate formation delivers substances to eliminate injurious agents, and the resulting increase in interstitial hydrostatic pressure leads to increased fluid uptake by lymphatic capillaries.

A) True
B) False

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Which cell type is targeted by the human immunodeficiency virus (HIV) ?


A) Cytotoxic T-lymphocyte
B) Memory B-lymphocyte
C) Helper T-lymphocyte
D) Natural killer cell
E) Plasma cell

F) All of the above
G) A) and B)

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A membrane attack complex is a protein grouping that


A) triggers phagocytosis of a target cell by a nearby macrophage or neutrophil.
B) forms a channel in the target cell membrane that causes cytolysis.
C) links a pathogen to a red blood cell so that it is carried to the liver or spleen.
D) stimulates basophils to attack a multicellular parasite in the body.

E) A) and C)
F) B) and C)

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In addition to creating a physical barrier to pathogen entry, mucus contains antimicrobial substances such as IgA.

A) True
B) False

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Opsonization involves


A) cross-linking several antigens together so that they are no longer soluble, and it is facilitated by the Fc region of the antibody.
B) marking a target for phagocytosis, and it is facilitated by interaction of the Fc region of the antibody with a phagocyte.
C) activation of NK cells, and it is a function of the antigen-binding site of the antibody.
D) fixation of antibodies in the IgG and IgM classes, and it involves the antigen-binding site of the antibody.

E) B) and C)
F) B) and D)

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Complement facilitates inflammation by activating basophils and mast cells and by attracting macrophages and neutrophils.

A) True
B) False

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An individual gets a snake bite and goes to the hospital to receive antibodies against the venom. This individual is acquiring


A) passive immunity.
B) active immunity.

C) A) and B)
D) undefined

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Vaccines are effective because they


A) immediately stimulate cellular immunity to eliminate all of the pathogen in the body.
B) inhibit antibodies from having secondary responses.
C) stimulate the development of immunologic memory.
D) increase the number of natural killer cells while decreasing the numbers of T and B cells.

E) A) and C)
F) A) and D)

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Which type of antibody is formed in response to parasitic infections and allergies, and has the effect of activating mast cells and basophils?


A) IgA
B) IgB
C) IgD
D) IgE
E) IgG

F) None of the above
G) A) and D)

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The site of infection is the location at which lymphocytes


A) are formed.
B) provide an effector response.
C) are activated.
D) become able to recognize one specific foreign antigen.

E) A) and D)
F) B) and C)

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When they leave the red marrow, pre-T-lymphocytes have


A) only the CD4 protein.
B) only the CD8 protein.
C) both the CD4 and CD8 proteins.
D) neither the CD4 nor CD8 protein.
E) either the CD4 or CD8 protein.

F) B) and E)
G) All of the above

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Negative selection is the process by which cells learn self-tolerance.

A) True
B) False

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Over their life span, plasma cells produce hundreds of millions of antibodies against one specific antigen.

A) True
B) False

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The first signal during helper T-lymphocyte activation involves


A) BCR of the helper T-cell binding with free antigen and engulfing it.
B) CD8 of the helper T-cell binding with MHC class III of the antigen-presenting cell.
C) CD4 of the helper T-cell binding with MHC class I part of the antigen fragment.
D) CD4 of the helper T-cell binding with MHC class II of the antigen-presenting cell.

E) None of the above
F) A) and B)

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What are the five main classes of immunoglobulins found in humans?


A) IgA, IgC, IgE, IgG, IgI
B) IgD, IgE, IgG, IgM, IgS
C) IgB, IgD, IgE, IgG, IgM
D) IgA, IgB, IgC, IgD, IgE
E) IgA, IgD, IgE, IgG, IgM

F) A) and C)
G) A) and E)

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E

Most activated B-lymphocytes differentiate into


A) memory helper T-lymphocytes.
B) macrophages.
C) plasma cells.
D) antigen-presenting cells.

E) A) and D)
F) A) and C)

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C

Describe the structure of an antibody. What type of molecule is it? What is its shape, how many parts does it have, and how do the parts differ?

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Antibodies are Y-shaped protei...

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The second signal during cytotoxic T-lymphocyte activation involves stimulation of the cell by interleukin 2 released by helper T-lymphocytes.

A) True
B) False

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Elevated antibody production during a primary response generally lasts for months or years, whereas antibody production in secondary responses decreases to baseline level generally within a couple of weeks.

A) True
B) False

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Select all that occur as a result of inflammation. A) Destruction of pathogens B) Remove cellular debris C) Allow for tissue repair D) Limiting the spread of an infectious agent

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A, B, C, D

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