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The function of helper T-lymphocytes is to


A) initiate and oversee the immune response.
B) turn off the immune response once it has been activated.
C) secrete toxins to kill or disable pathogens.
D) trigger cell death by disrupting metabolic activities.
E) All choices are correct.

F) B) and E)
G) B) and C)

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If T-lymphocytes that failed the negative selection test were not destroyed, the immune system would likely


A) cause autoimmune disorders.
B) exhibit very delayed activity.
C) be unable to recognize a particular class of pathogen.
D) exhibit more negative membrane potentials.

E) None of the above
F) C) and D)

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As T-lymphocytes leave the thymus, they are


A) naive and not yet competent.
B) naive and immunocompetent.
C) activated but not yet competent.
D) activated and immunocompetent.

E) C) and D)
F) B) and D)

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Protozoans are obligate intracellular parasites.

A) True
B) False

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MHC class II molecules are loaded with exogenous antigen after the antigen has been digested into fragments within a phagolysosome.

A) True
B) False

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Consuming meat that has been infected with a prion can lead to the disease


A) trichomoniasis.
B) bovine spongiform encephalopathy.
C) clostridium tetani.
D) histoplasmosis.

E) B) and D)
F) All of the above

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A fever ________ reproduction of bacteria and ________ CAMs on the endothelium of capillaries of lymph nodes.


A) stimulates; increases
B) stimulates; decreases
C) inhibits; increases
D) inhibits; decreases

E) A) and B)
F) All of the above

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Some biologists have criticized the traditional analogy of the immune system to an army, arguing that it is unnecessarily militaristic. They have proposed other analogies that compare immune functioning to gardening or housekeeping. Develop one of these or create your own analogy for immune function and describe the roles of helper T-lymphocytes, cytotoxic T-lymphocytes, and B-lymphocytes using language that fits your metaphor.

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Many answers are possible. Helper T-lymp...

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Eosinophils and lymphocytes are both types of leukocytes.

A) True
B) False

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When part of the immune system recognizes and binds to a foreign molecule, the part of the molecule to which binding occurs is called the epitope or ________ determinant.

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Which class of chemical messenger facilitates white blood cell formation in bone marrow?


A) Interleukins
B) Colony-stimulating factors
C) Tumor necrosis factors
D) Interferons

E) B) and C)
F) A) and D)

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When an antibody covers the region of a virus that the virus uses to bind to a cell receptor, that covering function is known as ________.

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"Complement" refers to a group of


A) white blood cells.
B) antibodies.
C) plasma proteins.
D) molecules on the surface of pathogenic microbes.

E) B) and D)
F) B) and C)

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The inflammatory response includes a decrease in the permeability of capillaries to prevent excessive blood loss after injury.

A) True
B) False

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Cytotoxic T-lymphocytes destroy infected cells by


A) increasing the permeability of infected cells and inducing apoptosis.
B) increasing the permeability of infected cells and preventing apoptosis.
C) decreasing the permeability of infected cells and inducing apoptosis.
D) decreasing the permeability of infected cells and preventing apoptosis.

E) C) and D)
F) None of the above

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The second signal during B-lymphocyte activation involves stimulation from


A) IL-2 released by cytotoxic T-lymphocytes.
B) IL-4 released by helper T-lymphocytes.
C) bradykinin released by antigen-presenting cells.
D) antibodies released by antigens.

E) B) and D)
F) A) and C)

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Agglutination of mismatched blood is a function of


A) IgD, which is a dimer.
B) IgD, which is a pentamer.
C) IgM, which is a dimer.
D) IgM, which is a pentamer.

E) B) and C)
F) B) and D)

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Which is not an action of interferon?


A) It stimulates macrophages and NK cells to destroy virus-infected cells.
B) It triggers synthesis of enzymes that destroy viral nucleic acids.
C) It signals the immune system that the secreting cell is part of the body and so should not be attacked.
D) It binds to receptors of neighboring cells preventing them from being infected.

E) A) and B)
F) B) and C)

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Compared to most interstitial fluid in the body, the interstitial fluid of an inflamed area would have a lower osmolarity and a lower concentration of proteins.

A) True
B) False

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Which of the following lists the body's first, second, and third lines of defense in order?


A) Adaptive immunity, external innate immunity, internal immunity
B) External innate immunity, internal innate immunity, adaptive immunity
C) External innate immunity, adaptive immunity, internal innate immunity
D) External adaptive immunity, internal adaptive immunity, innate immunity
E) Innate immunity, internal adaptive immunity, internal innate immunity

F) None of the above
G) D) and E)

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