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Which is the best explanation for how ibuprofen works?


A) It thins the blood to relieve joint pain.
B) It inhibits cyclooxygenase-2, which is needed to produce prostaglandins.
C) It activates cyclooxygenase-2, which then produces more prostaglandins.
D) It down-regulates the production of substance P.

E) B) and C)
F) A) and B)

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How could you improve your experiment?


A) Apply the hormone to mouse cell culture.
B) Apply the hormone at a concentration of 0.5M.
C) Hydrolyze the hormone before application.
D) Add ATP as a cofactor.

E) B) and D)
F) B) and C)

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You are a professor supervising first year medical students.One student is examining the adrenal gland of his cadaver."Wow!" he exclaims, "This person must have had an endocrine problem.Their adrenal gland lacks any kind of duct connecting it to the bloodstream.The hormones could only have oozed out." How do you respond?


A) "That makes their adrenal gland similar to an exocrine organ."
B) "Do you see signs of adrenal insufficiency, such as low fat stores or muscle degeneration?"
C) "That's normal.The hormones ooze out and diffuse into nearby capillaries, which is why endocrine glands are sometimes called 'ductless glands'."
D) "Look carefully and you will see the nerves that transport the hormones into the bloodstream."

E) All of the above
F) A) and B)

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Which of the following is NOT a function of oxytocin?


A) pair bonding
B) milk-ejection reflex
C) milk production
D) uterine contractions

E) B) and C)
F) All of the above

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Estrogen and testosterone are steroid hormones that differ by only a few atoms.The different receptor binding properties those differences confer allow the hormones to do what during development?


A) Cause differential maturation of the prefrontal cortex during late adolescence.
B) Cause a slight increase in muscle mass in females versus males.
C) Make females naturally attracted to pink and males to blue.
D) Control development of all sex-specific physical traits including sex organs, body hair, and breasts.

E) A) and D)
F) B) and D)

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A novel disease causes destruction of the adrenal glands.If a patient with this disease failed to receive aldosterone replacement therapy, what would result?


A) death
B) diminished cognitive function
C) infertility in both men and women
D) poor blood sugar regulation

E) B) and C)
F) A) and B)

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The use of bovine growth hormone (BGH) to increase milk yield in dairy cows is highly controversial.What other hormone is regularly added to milk, yet causes little controversy?


A) vitamin A
B) vitamin D
C) MSG
D) preservatives

E) A) and C)
F) None of the above

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ACTH stands for adrenocorticotropic hormone, but it is produced in the anterior pituitary.What is the basis of this name?


A) It is expressed most highly in tropical climates.
B) It stimulates the adrenal cortex.
C) It signals to the kidneys to reabsorb water.
D) It stimulates appetite by acting on the cerebral cortex.

E) B) and C)
F) A) and B)

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What hormone stimulates milk production in mammals?


A) aldosterone
B) melatonin
C) prolactin
D) luteinizing hormone

E) None of the above
F) A) and B)

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Which of the following is a paracrine regulator that affects almost every organ in the body?


A) insulin
B) testosterone
C) prostaglandin
D) gonadotropin

E) A) and D)
F) All of the above

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Oxytocin is a peptide hormone that causes uterine contractions in childbirth and stimulates milk secretion from nipples.Do men have oxytocin?

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What is the primary function of the hormone ADH?


A) regulates biological rhythms
B) mediates adaptation to long term stress
C) stimulates bone breakdown
D) conserves water by stimulating its reabsorption from urine

E) B) and C)
F) A) and D)

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Which of the following hormones is NOT produced by the adrenal gland?


A) epinephrine
B) cortisol
C) prolactin
D) aldosterone

E) B) and C)
F) C) and D)

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Lampreys completely lack parathyroid glands.Suggest why these glands may be important for other vertebrates, but not for jawless fish.


A) Because they are parasitic, lampreys get plenty of calcium from their hosts.
B) Living in the ocean, they are surrounded by large amounts of sodium, chloride, and magnesium ions.
C) Jawless fish employ a different system than other vertebrates to regulate blood sugar.
D) Since they have a cartilaginous skeleton but not true bone, they have less need to regulate calcium levels.

E) A) and B)
F) B) and D)

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What hormone stimulates the milk-ejection reflex?


A) antidiuretic hormone
B) oxytocin
C) vasopressin
D) parathyroid hormone

E) A) and B)
F) None of the above

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At the breakfast table, your roommate says, "Oops! I forgot to take my melatonin last night.I'd better take it now." How do you respond?


A) "Good idea -- you don't want your bones to get brittle."
B) "Be sure not to take too much, or your blood sugar could get dangerously low."
C) "Don't take it now - it regulates biological rhythms, and is normally high at night and low during the day."
D) "Don't take it after a meal - it promotes the 'fight-or-flight' response, not 'rest-and-digest'."

E) B) and D)
F) A) and B)

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What is the difference between the endocrine system and the autonomic nervous system?


A) The endocrine system employs chemical signals only, while the autonomic nervous system involves a combination of electrical and chemical signals.
B) The autonomic nervous system promotes "fight or flight" functions, while the endocrine system promotes "rest and digest" functions.
C) Norepinephrine is produced by the autonomic nervous system, while epinephrine is produced by the endocrine system.
D) The axons of neurons of the endocrine system travel a shorter distance than those of the autonomic nervous system.

E) C) and D)
F) None of the above

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A new hormone is discovered.Tests reveal that it is small, hydrophilic, and degraded by a protease.What type of hormone is it?


A) peptide
B) amino acid derivative
C) steroid
D) glucocorticoid

E) A) and B)
F) A) and C)

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The ________ lobe of the pituitary gland appears fibrous because it contains axons originating from hypothalamic neurons.


A) anterior
B) posterior
C) superior
D) inferior

E) A) and C)
F) B) and C)

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Which hormone is secreted by alpha cells of the pancreas in response to hypoglycemia?


A) glucagon
B) insulin
C) glucose
D) cortisol

E) A) and B)
F) B) and D)

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