Question 1

Linkage disequilibrium is the tendency for

Accepted Answer

A)  be totally randomized during meiosis.
B)  be non-randomly associated during meiosis.
C)  to be rearranged during meiosis because of crossing over.
D)  link together within certain blocks along the chromosome.E) B) and C)
F) A) and D)

Question 2

The majority of DNA in a human can be described as

Accepted Answer

A)  composed of short interspersed elements.
B)  non-coding.
C)  simple sequence repeats.
D)  segmental duplications.E) B) and C)
F) A) and C)

Question 3

In vertebrates, the family of myogenic regulatory factors (MRFs)  plays a major role in muscle development.This family consists of four related genes which have distinct but overlapping functions.This gene family is represented by only a single gene in Drosophila, called nautilus.You want to know whether nautilus plays a role like all of the MRFs put together, or more like one in particular.What is a quick and easy way to begin to address this question?

Accepted Answer

A)  Compare the DNA and protein sequences of all the genes to determine if nautilus is more similar to one MRF than another.
B)  Use a DNA microarray to compare gene activation patterns between nautilus and the MRFs.
C)  Compare the proteome of a cell expressing nautilus to the those of cells expressing each of the MRFs in turn.
D)  Generate four transgenic Drosophila strains that express the MRFs in a mutant nautilus background.E) All of the above
F) A) and B)

Question 4

When comparing the actual number of genes, the organism with the highest number is

Accepted Answer

A)  rice.
B)  human.
C)  fruit fly.
D)  yeast.E) C) and D)
F) B) and C)

Question 5

The inclusive term that describes all of the DNA in the nucleus of a cell is its

Accepted Answer

A)  genome.
B)  chromosome.
C)  gene.
D)  proteome.E) B) and C)
F) A) and D)

Question 6

The sequencing method that cuts the DNA of an entire chromosome into small fragments and then clones these fragments is called

Accepted Answer

A)  shotgun sequencing.
B)  clone-by-clone sequencing.
C)  RFLP sequencing.
D)  consensus sequencing.E) All of the above
F) B) and C)

Question 7

How did the rice genome project influence other genome projects?

Accepted Answer

A)  It was the first genome sequenced, so it proved it could be done.
B)  It sped up the genome analysis of other cereal crops, due to synteny.
C)  It sped up the analysis of the human genome, since rice has even more genes.
D)  It helped analysis of all genomes, since it was the basis of the ENCODE algorithms.E) None of the above
F) B) and D)

Question 8

Distances on a genetic map are measured in _____ units.

Accepted Answer

A)  centromere
B)  DNA
C)  dalton
D)  centimorganE) A) and C)
F) A) and B)

Question 9

Silent copies of genes that have been inactivated by mutations are called

Accepted Answer

A)  pseudogenes.
B)  clones.
C)  exons.
D)  introns.E) A) and D)
F) A) and C)

Question 10

Given a sequencing reaction length of approximately 500 successive nucleotides, what is the absolute minimum number of sequencing reactions needed to determine the complete human genome, excluding overlap and redundancy?

Accepted Answer

A)  3.1 billion
B)  6200
C)  12.4 million
D)  6.2 millionE) B) and D)
F) A) and D)

Question 11

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation, which involves

Accepted Answer

A)  shotgun cloning.
B)  the alignment of contigs.
C)  the identification of open reading frames.
D)  the construction of a genetic map.E) A) and B)
F) A) and C)

Question 12

The relative location of genes on a chromosome as determined by recombination frequencies is illustrated in a _______ map.

Accepted Answer

A)  DNA
B)  genetic
C)  chromosomal
D)  physicalE) B) and D)
F) A) and B)

Question 13

When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated that

Accepted Answer

A)  eukaryotic genomes are larger than prokaryotic genomes.
B)  eukaryotic genomes are smaller than prokaryotic genomes.
C)  the size of the organism determines the size of the genome.
D)  larger and more complex organisms have more genes than smaller, less complex organisms.E) None of the above
F) All of the above A

Question 14

Non-coding DNA regions within a gene are referred to as

Accepted Answer

A)  introns.
B)  exons.
C)  templates.
D)  transposons.E) None of the above
F) C) and D)

Question 15

The organism with the largest relative genome size is

Accepted Answer

A)  rice.
B)  human.
C)  fruit fly.
D)  yeast.E) B) and C)
F) B) and D)

Question 16

Recombination frequency between genes can be used to generate a

Accepted Answer

A)  genetic map.
B)  physical map.
C)  restriction map.
D)  haplotype map.E) B) and C)
F) None of the above

Question 17

The best technique for detecting chromosomal abnormalities is

Accepted Answer

A)  EST
B)  FISH
C)  STS
D)  SNPE) A) and B)
F) B) and D)

Question 18

Using actual landmarks within DNA sequences, scientists can generate a _______ map.

Accepted Answer

A)  genetic
B)  DNA
C)  physical
D)  chromosomalE) B) and D)
F) None of the above

Question 19

The reason segmental duplications pose a logistical challenge in the proper alignment of DNA sequences is that they

Accepted Answer

A)  are inherently repetitive.
B)  contain large numbers of LINEs, which interfere with sequence annotation.
C)  interfere with BLAST analysis.
D)  are often found in areas of constitutive heterochromatin.E) None of the above
F) A) and B) A

Question 20

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Accepted Answer

A)  synteny.
B)  exosymbiosis.
C)  endosymbiosis.
D)  draft sequencing by the nucleosome.E) A) and B)
F) A) and D) C

Exam 18: Genomics

Linkage disequilibrium is the tendency for

Correct Answer
verified

The majority of DNA in a human can be described as

Correct Answer
verified

Correct Answer
verified

When comparing the actual number of genes, the organism with the highest number is

Correct Answer
verified

The inclusive term that describes all of the DNA in the nucleus of a cell is its

Correct Answer
verified

The sequencing method that cuts the DNA of an entire chromosome into small fragments and then clones these fragments is called

Correct Answer
verified

How did the rice genome project influence other genome projects?

Correct Answer
verified

Distances on a genetic map are measured in _____ units.

Correct Answer
verified

Silent copies of genes that have been inactivated by mutations are called

Correct Answer
verified

Given a sequencing reaction length of approximately 500 successive nucleotides, what is the absolute minimum number of sequencing reactions needed to determine the complete human genome, excluding overlap and redundancy?

Correct Answer
verified

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation, which involves

Correct Answer
verified

The relative location of genes on a chromosome as determined by recombination frequencies is illustrated in a _______ map.

Correct Answer
verified

When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated that

Correct Answer
verified
A

Non-coding DNA regions within a gene are referred to as

Correct Answer
verified

The organism with the largest relative genome size is

Correct Answer
verified

Recombination frequency between genes can be used to generate a

Correct Answer
verified

The best technique for detecting chromosomal abnormalities is

Correct Answer
verified

Using actual landmarks within DNA sequences, scientists can generate a _______ map.

Correct Answer
verified

The reason segmental duplications pose a logistical challenge in the proper alignment of DNA sequences is that they

Correct Answer
verified
A

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Correct Answer
verified
C

Exam 18: Genomics

Linkage disequilibrium is the tendency for

Correct AnswerverifiedShow Answer

The majority of DNA in a human can be described as

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

When comparing the actual number of genes, the organism with the highest number is

Correct AnswerverifiedShow Answer

The inclusive term that describes all of the DNA in the nucleus of a cell is its

Correct AnswerverifiedShow Answer

The sequencing method that cuts the DNA of an entire chromosome into small fragments and then clones these fragments is called

Correct AnswerverifiedShow Answer

How did the rice genome project influence other genome projects?

Correct AnswerverifiedShow Answer

Distances on a genetic map are measured in _____ units.

Correct AnswerverifiedShow Answer

Silent copies of genes that have been inactivated by mutations are called

Correct AnswerverifiedShow Answer

Given a sequencing reaction length of approximately 500 successive nucleotides, what is the absolute minimum number of sequencing reactions needed to determine the complete human genome, excluding overlap and redundancy?

Correct AnswerverifiedShow Answer

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation, which involves

Correct AnswerverifiedShow Answer

The relative location of genes on a chromosome as determined by recombination frequencies is illustrated in a _______ map.

Correct AnswerverifiedShow Answer

When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated that

Correct AnswerverifiedA

Non-coding DNA regions within a gene are referred to as

Correct AnswerverifiedShow Answer

The organism with the largest relative genome size is

Correct AnswerverifiedShow Answer

Recombination frequency between genes can be used to generate a

Correct AnswerverifiedShow Answer

The best technique for detecting chromosomal abnormalities is

Correct AnswerverifiedShow Answer

Using actual landmarks within DNA sequences, scientists can generate a _______ map.

Correct AnswerverifiedShow Answer

The reason segmental duplications pose a logistical challenge in the proper alignment of DNA sequences is that they

Correct AnswerverifiedA

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Correct AnswerverifiedC

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A

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C