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Who proposed that in any DNA molecule, A =T and G = C?


A) Hershey and Chase
B) Chargaff
C) Franklin
D) Watson and Crick

E) None of the above
F) A) and B)

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Avery, MacLeod, and McCarty's experiments revealed that the transforming principle had all of the following properties except


A) its activity was destroyed by treatment with proteases.
B) its activity was unaffected by RNA-digesting enzymes.
C) its activity was unaffected by lipid extraction.
D) its activity was destroyed by treatment with DNA endonucleases.

E) A) and D)
F) A) and C)

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The synthesis of a growing strand of DNA is carried out by adding nucleotides to the ___ end of an existing strand.


A) 2'
B) 3'
C) 5'
D) 1'

E) B) and D)
F) A) and B)

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Chargaff's rules for the pairing of nitrogen bases is


A) A = C and G = T.
B) A = T and G =C.
C) A = G and C = T.

D) None of the above
E) All of the above

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Which is not a component of nucleic acids?


A) organic nitrogenous base
B) pentose sugar
C) phosphate
D) sulfur

E) B) and C)
F) A) and D)

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DNA consists of two antiparallel strands of nucleotides held together by


A) peptide bonds.
B) covalent bonds.
C) ionic bonds.
D) hydrogen bonds.

E) A) and B)
F) A) and C)

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Deoxyribose has a carbon atom that is not part of the pentose ring.In a nucleotide, what is attached to this carbon?


A) a nitrogenous base
B) a phosphate group
C) three hydrogen atoms
D) one hydrogen atom

E) B) and C)
F) A) and D)

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B

When a mixture of live nonvirulent bacteria and dead virulent bacteria was injected into mice, Griffith unexpectedly found that the injected mice died.He explained this result by suggesting that the nonvirulent bacteria are being


A) activated.
B) transformed.
C) translated.
D) transcribed.

E) A) and D)
F) All of the above

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B

During replication, which enzyme unwinds the DNA double helix?


A) DNA primase
B) DNA polymerase I
C) DNA helicase
D) DNA gyrase

E) C) and D)
F) A) and C)

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An organism has been found to contain a defective form of photolyase.What function might be impaired in this organism?r


A) Lengthening of the tips of chromosomes
B) Repair of DNA damage caused by UV light
C) Stabilization of single-stranded DNA during DNA replication
D) Recognition of damaged DNA by the UvrABC complex

E) A) and B)
F) A) and C)

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DNA replication always proceeds by adding new bases to the _______ end of an existing strand.


A) 1'
B) 2'
C) 3'
D) 4'

E) A) and B)
F) A) and C)

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Genetic analysis indicates that an unknown organism contains a gene that codes for a defective form of telomerase.Based on this information alone, you can conclude that this organism


A) is prokaryotic.
B) is eukaryotic.
C) has unusually long telomeres.
D) has an increased risk of developing cancer.

E) B) and D)
F) All of the above

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Avery and his coworkers showed that the agent responsible for changing nonvirulent bacteria into virulent bacteria was


A) protein.
B) polysaccharide.
C) DNA.
D) RNA.

E) A) and D)
F) None of the above

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After DNA replication is complete, each strand of the original molecule is bound to a new complementary strand.This process is known as


A) disruptive replication.
B) conservative replication.
C) semiconservative replication.
D) dispersive replication.

E) C) and D)
F) B) and C)

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In DNA, complementary nitrogen bases are held together by


A) nitrogen bonds.
B) hydrogen bonds.
C) hydrophobic bonds.
D) peptide bonds.

E) B) and C)
F) C) and D)

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The site where the two original DNA strands separate and active replication occurs is called the


A) replication fork.
B) replisome.
C) primosome.
D) lagging strand.

E) B) and D)
F) All of the above

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A

Who proposed that the structure of DNA is a double helix with two polynucleotide chains running in opposite directions and held together by hydrogen bonding between pairs of nitrogenous bases?


A) Hershey and Chase
B) Chargaff
C) Franklin
D) Watson and Crick

E) B) and C)
F) None of the above

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Griffith, a British microbiologist, used bacteria and mice to demonstrate the process of transformation.During transformation,


A) a bacterial chromosome produces an exact copy of itself.
B) the nucleus of a mouse cell repairs itself when damaged by bacterial infection.
C) DNA from an infected mouse cell changes bacteria from a non-pathogenic to a pathogenic form.
D) genetic material is transferred from one bacterial cell to another.

E) All of the above
F) A) and B)

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Which of the following statements about DNA replication is false?


A) The two strands are separated.
B) Each existing strand is used as a template for making a new strand.
C) Synthesis of both new strands is in the 5' to 3' direction.
D) The newly synthesized DNA is packaged into one nucleus, and the original DNA is packaged into another nucleus.

E) C) and D)
F) B) and D)

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Which enzyme adds new nucleotides to the end of a growing strand?


A) ligase
B) polymerase
C) gyrase
D) helicase

E) B) and C)
F) A) and D)

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