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Cytochromes contain a heme group similar to that in hemoglobin.The iron atom (Fe) in the center of the group can be oxidized and reduced.If someone was suffering from iron deficiency anemia, what stage of cellular respiration would be most affected?


A) Glycolysis
B) The Krebs cycle
C) The electron transport chain
D) Fermentation

E) A) and C)
F) None of the above

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In the absence of oxygen, can cells utilize the electron transport chain?


A) Yes, all cells can make use of the electron transport chain in the absence of oxygen via fermentation.
B) No, oxygen is a required cofactor for the complexes in the electron transport chain.
C) Yes, in the case that a cell can use a terminal electron acceptor other than oxygen, it can make use of the electron transport chain.
D) No, oxygen is the primary electron acceptor in electron transport chains in all cell types.

E) All of the above
F) None of the above

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You decide to go on vacation in the mountains, where you are staying in a cabin.Unfortunately, when you turn on the water in the cabin you smell hydrogen sulfide (H2S) gas.After some research, you find out that the H2S may be due to the presence of sulfur bacteria living in your pipes.What molecule do these bacteria use as an electron acceptor?


A) O2
B) H20
C) SO4
D) H2S

E) A) and B)
F) All of the above

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To form NADH from NAD+, two electrons and a proton are removed from an organic molecule.What term best describes the reaction in which electrons and a proton are removed from an organic molecule?


A) Condensation
B) Reduction
C) Dehydrogenation
D) Decarboxylation

E) C) and D)
F) All of the above

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The energy released in the mitochondrial electron transport chain is used to transport proteins into the.


A) mitochondrial matrix.
B) cytoplasm.
C) endoplasmic reticulum.
D) intermembrane space of the mitochondria.

E) A) and D)
F) B) and D)

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In the reaction catalyzed by aconitase, the conversion of citrate to isocitrate is inhibited by fluoroacetate.Fluoroacetate is used as a pesticide.Why is this an effective pesticide?


A) It inhibits glycolysis
B) It inhibits pyruvate oxidation
C) It inhibits the Krebs cycle
D) It inhibits the electron transport chain

E) All of the above
F) A) and C)

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What must happen to amino acids before they can be used in catabolic reactions?


A) They must be decarboxylated
B) They must be deoxygenated
C) They must be dehydrogenated
D) They must be deaminated

E) None of the above
F) B) and C)

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What important metabolic intermediate does not cross the inner membrane of the mitochondria?


A) ATP
B) Acetyl-CoA
C) Pyruvate
D) Oxygen

E) A) and B)
F) All of the above

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What happens to the oxygen that is used in cellular respiration?


A) It is converted to carbon dioxide
B) It is used to make glucose
C) It is used to make Krebs cycle intermediates
D) It is reduced to form water

E) A) and B)
F) A) and C)

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If citrate levels are high in the cell, but ATP levels are low, what do you think will happen in the cell?


A) In the presence of glucose, glycolysis will run to generate energy for the cell, but the Krebs cycle will be inhibited.
B) Glycolysis will be inhibited, but the Krebs cycle will be functional, allowing it to be utilized to breakdown acetyl-CoA generated from beta-oxidation.
C) The electron transport chain will be inhibited, causing a build-up of NADH and FADH2.This will inhibit the Krebs cycle, but in the presence of glucose, glycolysis will still run coupled with fermentation to regenerate NAD+.
D) Glycolysis and the Krebs cycle will both be inhibited, thus under these conditions there will be no mechanism to generate ATP.

E) C) and D)
F) A) and B)

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Many of the antiviral drugs currently used to treat HIV/AIDS also interfere with an enzyme that helps mitochondria multiply.Treatment can therefore result in a decrease in the number of mitochondria found in certain tissues.Given this information, what might you expect to see in patients treated with antiviral drugs?


A) An increase in oxidative phosphorylation
B) An increase in phosphofructokinase activity
C) An increase in NADH dehydrogenase activity
D) An increase in lactic acid levels

E) All of the above
F) B) and C)

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Regardless of the electron or hydrogen acceptor used, one of the products of fermentation is always


A) ADP.
B) ATP.
C) NAD+.
D) pyruvate.

E) All of the above
F) B) and C)

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As a forensic pathologist, you have just completed an autopsy of a poisoning victim.After a thorough examination, you conclude that the victim died of cyanide poisoning.You know that cyanide binds to the cytochrome oxidase complex, and therefore list the official cause of death as suffocation due to cyanide exposure.However, if you wanted to provide a more technical explanation as to the cause of death, which process was specifically inhibited directly by cyanide?


A) The reduction of NAD+
B) The oxidation of FADH2
C) All proton pumping into the intermembrane space
D) The formation of water from oxygen

E) A) and B)
F) B) and C)

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Arsenic poisoning can lead to organ failure and death.Though arsenic can inhibit or interfere with a number of cellular enzymes, arsenic poisoning is thought to be mainly due to indirect inhibition of enzymes involved in both pyruvate oxidation and the Krebs cycle.As a result, this compound must be able to enter which cellular compartment?


A) The cytoplasm
B) The nucleus
C) The intermembrane space of the mitochondria
D) The mitochondrial matrix

E) A) and B)
F) A) and C)

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In order to lose weight and reduce body fat, a friend of yours has decided to eliminate all fat from his diet, while consuming unrestricted amounts of carbohydrates.What do you think of this idea?


A) It is a good idea, because if your friend doesn't eat any fat, he cannot store any additional fat.
B) It is a bad idea, because consumption of fat is required to provide cofactors for the electron transport chain.
C) It is a good idea, because under conditions where ATP levels are low in cells, carbohydrates will be stored, and fat stores will be catabolized via beta-oxidation to generate energy.
D) It is a bad idea, because if ATP levels are high in cells, excess acetyl-CoA from the metabolism of carbohydrates can be used for fatty acid synthesis.

E) All of the above
F) A) and C)

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D

What oxidizing agent is used to temporarily store high energy electrons harvested from glucose molecules in a series of gradual steps in the cytoplasm?


A) FADH2
B) ADP
C) NAD+
D) Oxygen

E) All of the above
F) C) and D)

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How and where is ATP made in a eukaryotic cell?


A) ATP is only made in the mitochondria in response to chemiosmosis.
B) ATP is made in all compartments of the cell in response to endergonic reactions and is used to drive exergonic reactions in the cell.
C) ATP can be made by direct phosphorylation of ADP in the cytoplasm, and by an enzyme complex that uses the energy from a proton gradient to drive ATP synthesis in the mitochondria.It can also be made in other locations in the cell, depending on the cell type.
D) ATP can be made by an enzyme complex that uses the energy of protons moving down their concentration gradient from the mitochondrial matrix to the cytoplasm to make the ATP.

E) None of the above
F) B) and D)

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All of the reactions of cellular respiration that occur after glycolysis take place in what part of the eukaryotic cell?


A) The chloroplast
B) The nucleus
C) The mitochondria
D) The plasma membrane

E) A) and C)
F) A) and D)

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C

What is the oxidized form of the most common electron carrier that is needed for both glycolysis and the Krebs cycle?


A) ATP
B) FAD
C) pyruvate
D) NAD+

E) B) and D)
F) A) and B)

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What molecule can oxidize NADH?


A) Acetaldehyde
B) Lactate
C) Ubiquinone
D) Glucose

E) A) and B)
F) A) and C)

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A

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