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How do hormones and target cells recognize one another?


A) By signs
B) By the location of the target cells
C) By the presence of specific receptor molecules on or in the target cells
D) By the function of the target cells
E) By the location of the hormones

F) A) and D)
G) B) and D)

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Most hormones are regulated by ________ mechanisms.


A) negative-feedback
B) neural-feedback
C) positive-feedback
D) hormonal-feedback

E) B) and C)
F) A) and D)

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Which of the following occurs when a hormone binds to a nuclear receptor?


A) Activation of cyclic AMP
B) Activation of mRNA synthesis
C) Increased lipid synthesis by ribosomes
D) Opens membrane channels
E) Alters membrane permeability

F) A) and B)
G) B) and E)

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Increased testosterone levels reduce the secretion of gonadotropin-releasing hormone from the anterior pituitary. This is an example of


A) inhibition of hormone release by humoral stimuli.
B) inhibition of hormone release by neural stimuli.
C) inhibition of hormone release by external stimuli.
D) inhibition of hormonal release by environmental stimuli.
E) inhibition of hormone release by hormonal stimuli.

F) D) and E)
G) B) and C)

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The release of chemicals from an endocrine or exocrine gland is referred to as ________.


A) absorption
B) diffusion
C) filtration
D) secretion

E) A) and D)
F) C) and D)

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All of the following are reasons why some hormones need assistance to travel in the blood except


A) they are small enough to be easily digested by blood enzymes.
B) they are easily filtered from the blood into the kidney tubules.
C) they have low solubility in blood plasma due to their chemical nature.
D) they cannot dissolve in the blood because they are water-soluble.

E) A) and B)
F) B) and C)

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The role of cAMP when it acts as an intracellular mediator in cells is to


A) bind to and activate protein kinase.
B) directly activate genes in the nucleus to produce mRNA by binding to DNA.
C) directly activate structural enzymes in the cytoplasm of the target cell.
D) catalyze a cascade reaction that ultimately activates genes on the DNA.
E) control levels of calcium in the cell.

F) B) and E)
G) C) and D)

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Once a lipid-soluble hormone is conjugated in the liver


A) its half-life is increased.
B) it can be more quickly eliminated from the body.
C) it can be stored for later use.
D) it is actively transported into cells.
E) it is more slowly eliminated from the body.

F) A) and C)
G) A) and E)

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Which chemical class of hormone is more likely to need a binding protein for transport in the blood?


A) Water-soluble
B) Amino acid derivative
C) Protein
D) Lipid-soluble

E) B) and C)
F) A) and D)

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In general, the response of target cells to endocrine stimulation is ________ than their response to nervous stimulation.


A) faster and briefer
B) slower and more prolonged
C) more accurate
D) more restricted to a small area of the body
E) more intense

F) B) and E)
G) A) and C)

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Match the description with the type of receptor model. -Messenger RNA synthesis regulated


A) Nuclear receptor model
B) Membrane-bound receptor model

C) A) and B)
D) undefined

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Which type of chemical messenger is released from neurons to activate an adjacent cell?


A) Paracrine
B) Neurotransmitter
C) Autocrine
D) Endocrine

E) A) and C)
F) All of the above

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Which pattern of hormone secretion, represented by epinephrine, can have dramatic changes in its concentration and circulating levels?


A) Chronic hormone secretion
B) Long-term hormone secretion
C) Episodic hormone secretion
D) Acute hormone secretion

E) All of the above
F) C) and D)

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Match the description with the type of receptor model. -G-protein


A) Nuclear receptor model
B) Membrane-bound receptor model

C) A) and B)
D) undefined

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Blood chemistry changes are examples of ________ stimuli, whereas sympathetic nervous system impulses are examples of ________ stimuli for hormone release.


A) neural; humoral
B) positive; negative
C) negative; positive
D) humoral; neural

E) A) and D)
F) B) and C)

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Hormonal secretion can be regulated by


A) the action of a substance other than a hormone.
B) the nervous system.
C) other hormones.
D) All of the choices are correct.
E) None of the choices are correct.

F) A) and E)
G) B) and E)

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Changes in blood calcium levels affect the secretion of both PTH and calcitonin. PTH increases blood calcium levels but calcitonin decreases blood calcium levels. Calcium is therefore an humoral inhibitor of ________.


A) calcitonin
B) PTH
C) both PTH and calcitonin

D) A) and C)
E) A) and B)

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After a meal, blood glucose levels rise and stimulate the release of insulin. Of which type of stimulation is this an example?


A) Humoral
B) Neural
C) Hormonal
D) Hypothalamic

E) A) and D)
F) None of the above

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Sympathetic neurons can serve as ________ stimuli for hormone release from certain endocrine organs.


A) autocrine
B) humoral
C) paracrine
D) neural

E) B) and D)
F) B) and C)

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A water-soluble hormone binds to its receptor on the plasma membrane. Arrange the events that follow in correct sequence. (1) Alpha subunit-GTP complex alters cell activity (2) GTP binds to the alpha subunit replacing GDP (3) G-protein subunits separate from the receptor (4) Alpha subunit separates from other two subunits (5) G-protein subunits bind to the receptor


A) 5, 2, 3, 4, 1
B) 4, 2, 1, 3, 5
C) 5, 2, 1, 4, 3
D) 5, 4, 2, 1, 3
E) 3, 4, 1, 2, 5

F) A) and B)
G) A) and C)

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