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This is the principal cation of the ECF.


A) Ca₂+
B) Cl-
C) K+
D) Na+
E) Pi

F) None of the above
G) B) and D)

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is the most significant solute in determining the distribution of water among fluid compartments.


A) Na+
B) Cl-
C) Ca₂+
D) K+
E) Pi

F) B) and D)
G) A) and E)

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Excretion of phosphate


A) increases free potassium ions in the ECF.
B) increases free calcium ions in the ECF.
C) increases free chloride ions in the ICF.
D) decreases free potassium ions in the ECF.
E) decreases free calcium ions in the ECF.

F) A) and E)
G) C) and D)

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In acidosis, the membrane potential of nerve cells is , which the central nervous system.


A) repolarized; inhibits
B) depolarized; stimulates
C) hyperpolarized; depresses
D) depolarized; depresses
E) hyperpolarized; stimulates

F) B) and E)
G) A) and C)

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Uncompensated alkalosis is a pH imbalance that can only be corrected with clinical intervention.

A) True
B) False

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When the renal tubules secrete hydrogen ions into the tubular fluid, they at the same time.


A) secrete potassium
B) secrete sodium
C) reabsorb potassium
D) secrete chloride
E) reabsorb sodium

F) B) and C)
G) D) and E)

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The three physiological buffer systems are urinary, digestive, and respiratory.

A) True
B) False

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Most of the body water is in


A) the intracellular fluid (ICF) .
B) the extracellular fluid (ECF) .
C) tissue (interstitial) fluid.
D) blood plasma and lymph.
E) the transcellular fluid.

F) B) and D)
G) B) and E)

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These scenarios are related with hyperkalemia except


A) cells are more excitable.
B) resting membrane potential is more negative.
C) cells are partially depolarized.
D) cells are more sensitive to stimulation.
E) there is less diffusion of potassium out of the cells.

F) A) and B)
G) B) and D)

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Women have a tendency to retain water during part of the menstrual cycle because estrogen mimics the action of


A) ADH.
B) aldosterone.
C) atrial natriuretic hormone.
D) oxytocin.
E) prolactin.

F) C) and E)
G) A) and B)

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The total body water (TBW) content of a 70 kg young male is about


A) 10 L.
B) 20 L.
C) 40 L.
D) 60 L.
E) 70 L.

F) C) and E)
G) B) and C)

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A buffer system converts a weak acid or base into a strong one.

A) True
B) False

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When blood volume and pressure are too high


A) ADH release is inhibited.
B) ADH release is stimulated.
C) renal tubules reabsorb more water.
D) renal tubules reabsorb more sodium.
E) the kidneys produce less urine.

F) B) and D)
G) C) and D)

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The major chemical buffers systems of the body are the systems.


A) urinary and respiratory
B) urinary and digestive
C) bicarbonate, phosphate, and protein
D) bicarbonate, nucleic acids, and protein
E) bicarbonate, phosphate, and nitrate

F) A) and E)
G) None of the above

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Long-term inhibition of thirst is mostly associated with


A) cooling of the mouth.
B) distention of the stomach by ingested water.
C) a drop in blood osmolarity.
D) moistening of the mouth.
E) increased salivation.

F) A) and E)
G) A) and C)

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Breathing with the head inside a plastic bag can lead to


A) metabolic alkalosis.
B) metabolic acidosis.
C) urinary alkalosis.
D) urinary acidosis.
E) respiratory acidosis.

F) B) and C)
G) D) and E)

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An antiport system on the basal side of renal tubule cells


A) transports bicarbonate from the tubular fluid back into the tubule cells.
B) transports H+ in both directions across the epithelium.
C) transports CO₂ from the blood into the tubule cells.
D) exchanges K+ for Na+.
E) exchanges H+ for Na+.

F) A) and E)
G) A) and B)

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Proteins can buffer a drop in pH by their side groups and can buffer an increase in pH by their side groups.


A) -NH₂; -PO4
B) -PO4; -COOH
C) -NH₂; -COOH
D) -COOH; -NH₂
E) -PO4; -NH₂

F) A) and E)
G) D) and E)

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Osmosis from one fluid compartment to another is determined by


A) the temperature difference between compartments.
B) the relative concentration of solutes in each compartment.
C) the relative volume in each compartment.
D) the relative size of each compartment.
E) blood pressure.

F) B) and C)
G) A) and E)

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