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Which of the following is not true of Ebola and Marburg?


A) They transmitted by direct contact with body ?uids from affected individuals.
B) Blood clotting is disrupted in an infection with these viruses.
C) The viruses are transmitted by mosquitoes.
D) They are ?loviruses.
E) There is currently no effective treatment for infected individuals.

F) A) and E)
G) A) and D)

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The symptoms that occur in cyclic 48- to 72-hour episodes in a malaria patient are _______.


A) chills, fever, and sweating
B) sore throat, low grade fever, and swollen lymph nodes
C) bloody, mucus-filled stools, fever, diarrhea, and weight loss
D) urinary frequency and pain, and vaginal discharge
E) fever, swollen lymph nodes, and joint pain

F) All of the above
G) A) and E)

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Several infections of the cardiovascular system can be identi?ed by inspecting a stained blood smear in the microscope. For the following infections, identify the microscope observation that does not ?t the disease.


A) Chagas disease; protozoan visible among blood cells
B) Epstein-Barr virus; virus visible inside red blood cells
C) Babesiosis; protozoan visible inside red blood cells
D) Malaria; ring trophozoites visible inside red blood cells

E) A) and B)
F) All of the above

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After a Drug Enforcement Agency raid on a location that housed intravenous drug users, several were brought to the hospital with rapid breathing, fever, and an altered mental state. Which of the following statements is correct?


A) Many drug users are HIV-positive, so the patients should all be monitored for levels of CD4 T-cells before any other action is taken.
B) A broad-spectrum antibiotic is needed promptly, as they are likely to be in septic shock from intravenous introduction of microbes into the blood.
C) Unsanitary conditions in the house probably resulted in infestations with insects, so it's prudent to examine them for insect bites that may provide a clue.
D) Stained blood smears should be performed promptly to look for abnormalities in the blood cells.

E) A) and C)
F) All of the above

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Which of the following infectious agents and means of disposal are mismatched?


A) Drums made with animal hides should be treated with sterilizing gas to eliminate endospores.
B) Coagulation factors purified from blood must be heat-treated to destroy HIV.
C) Carcasses of animals that died of anthrax must be incinerated to avoid endospores entering the soil.
D) Mosquito bed nets must be washed in bleach weekly to eliminate any residual Plasmodium.

E) A) and B)
F) B) and C)

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For the following list of anti-HIV drugs and their mechanism of action. Identify the mismatch.


A) Protease inhibitor - blocks the active site of the protease required for assembling new viral particles
B) Integrase inhibitor - blocks the active site of the enzyme required to splice HIV DNA into the human genome
C) Reverse transcriptase inhibitor - blocks the active site of the enzyme required to convert viral RNA to DNA
D) AZT (azidothymidine) - as an analog of thymidine, it is incorporated into viral RNA in place of thymidine

E) B) and C)
F) A) and B)

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Which of the following is incorrect regarding Yersinia pestis?


A) It is a gram-negative rod.
B) It has a capsule as a virulence factor.
C) It produces coagulase as a virulence factor.
D) It produces an enterotoxin.
E) It exhibits bipolar staining and appears to resemble a safety pin.

F) All of the above
G) A) and B)

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Aedes mosquitoes are the vectors involved in Chikungunya and dengue fever.

A) True
B) False

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Which of the following statements is incorrect regarding malaria?


A) The mosquito inoculates human blood with sporozoites.
B) Trophozoites develop in red blood cells.
C) Gametocytes enter the mosquito as she draws a blood meal from a human.
D) Merozoites enter and multiply in liver cells.

E) B) and D)
F) C) and D)

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Plague is a quarantinable disease.

A) True
B) False

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Acute endocarditis is most commonly contracted through ______.


A) parenteral entry
B) droplets
C) fomites
D) casual contact
E) ingestion

F) None of the above
G) A) and E)

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Plague exhibits a _______.


A) septic form historically called the Black Death
B) bubonic form in which swollen lesions termed buboes develop
C) pneumonic form that manifests as a respiratory disease
D) All of the choices are correct.

E) B) and C)
F) B) and D)

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A frequent cancer that is seen in AIDS patients is ______.


A) leukemia
B) melanoma
C) Kaposi's sarcoma
D) Hodgkin's lymphoma
E) myeloma

F) A) and E)
G) B) and C)

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Bubonic plague is transmitted by ______.


A) fomites
B) rats
C) sexual contact
D) mosquitoes
E) ?eas

F) A) and B)
G) D) and E)

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Which of the following statements regarding sepsis is incorrect?


A) The presence of microbes in the blood results in increased viscosity, and a rise in blood pressure is a hallmark of sepsis.
B) Both gram-negative and gram-positive bacteria in the blood can induce sepsis.
C) A sample of blood plated on a variety of bacterial media is a good method to identify the causative organism in sepsis.
D) The Gram-negative cell envelope stimulates an inflammatory response that leads to endotoxic shock.

E) A) and D)
F) None of the above

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Which of the following statements is incorrect regarding subacute endocarditis?


A) Bacteria colonize previously damaged heart tissue resulting in biofilm growth.
B) It is caused by autoantibodies that inappropriately target heart and valve tissue.
C) It can be caused by oral bacteria that are introduced to the blood by dental procedures.
D) It occurs exclusively in patients that have prior heart damage.

E) B) and C)
F) A) and B)

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Documented transmission of HIV involves ______.


A) contaminated food
B) mosquitoes
C) unprotected sexual intercourse or contact with blood/blood products
D) respiratory droplets

E) A) and D)
F) C) and D)

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The gram-negative bacillus associated with abscesses from cat bites or scratches is _______.


A) Salmonella typhimurium
B) Francisella tularensis
C) Bartonella henselae
D) Brucella suis
E) Yersinia pestis

F) C) and D)
G) All of the above

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Lyme disease is only seen in people living in Lyme, Connecticut.

A) True
B) False

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Which of the following is not associated with sepsis?


A) Respiratory acidosis
B) Fever and shaking chills
C) Parenteral or endogenous transfer
D) Endotoxic shock
E) Drop in blood pressure

F) B) and E)
G) B) and D)

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