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Based on new information from the Human Microbiome Project, the human body typically begins to be colonized by its normal biota _______.


A) before birth, in utero
B) during and immediately after birth
C) when a child first goes to school
D) when an infant gets its first infectious disease
E) during puberty

F) A) and E)
G) A) and D)

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An intermediary inanimate object from which an infectious agent is acquired is termed a _______.


A) fomite
B) carrier
C) vector
D) reservoir

E) All of the above
F) B) and C)

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The effect of beneficial microbes of normal biota against invading microbes is called ______.


A) microbial antagonism
B) endogenous infection
C) infectious disease
D) axenic
E) gnotobiotism

F) C) and D)
G) A) and B)

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A laboratory technologist splashed a blood specimen onto his face, eyes, nose, and mouth. This specimen was from an HIV positive patient. If this blood exposure leads to HIV infection in thetechnologist, the transmission route is _______.


A) direct
B) fomite
C) vehicle
D) droplet nuclei
E) aerosol

F) C) and D)
G) A) and E)

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You are studying a newly identi?ed infectious disease within a population. Think of the typical graph of the course of infection--incubation period through to convalescent period. The new disease reveals a course of infection characterized by ?uctuating symptoms, with intermittent periods of Invasion (acute period) between prodromal periods. The whole course of infection occurs over a period of months or even years. Based upon the information presented, select the statement that most accurately re?ects this new infectious disease.


A) This infectious disease exhibits latency.
B) This is not an infectious disease at all.
C) The host has immune problems and this is the typical course of a disease for that population.
D) Viral infections always present with this type of disease course.

E) A) and B)
F) A) and C)

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Animals that participate in the life cycles of pathogens and transmit pathogens from host to host are ______.


A) fomites
B) aerosols
C) mechanical vectors
D) droplet nuclei
E) biological vectors

F) A) and E)
G) None of the above

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A sign is _______.


A) an objective indication of disease
B) a subjective indication of disease
C) measurable by health care personnel
D) malaise and body aches
E) an objective indication of disease that is measurable by health care personnel

F) B) and C)
G) C) and E)

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The su?x -osis means ______.


A) blood
B) a disease or morbid process
C) an in?ammation
D) tumor
E) pertaining to

F) A) and E)
G) None of the above

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Pathogenic microbes that cause disease in healthy people are called ______.


A) opportunistic pathogens
B) normal biota
C) indigenous biota
D) true pathogens
E) micropathogens

F) A) and E)
G) None of the above

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Which of the following is an example of sequelae?


A) Headache from meningitis
B) Di?culty swallowing from streptococcal infection
C) Arthritis from Lyme disease
D) Diarrhea from Salmonella enteritidis infection

E) A) and D)
F) None of the above

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A pathologic state begins with contact with a microbe.

A) True
B) False

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Koch's postulates are easily satisfied for viral diseases.

A) True
B) False

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The objective, measurable evidence of disease evaluated by an observer is termed a/an ______.


A) syndrome
B) symptom
C) sign
D) pathology
E) inflammation

F) A) and B)
G) A) and E)

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Carriers that shed and transmit pathogens while they are recovering from an infectious disease are called ______ carriers.


A) asymptomatic
B) passive
C) incubation
D) chronic
E) convalescent

F) A) and E)
G) A) and B)

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The terms pathogenicity and virulence can be used synonymously because they both refer to an organism's ability to cause disease.

A) True
B) False

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All of the following are examples of epigenetic changes except _______.


A) histones are altered, which affects replication and transcription
B) microbial mucinase digests the protective lining of mucous membranes
C) host cell genome is altered, interrupting transcription
D) microbe binds to small RNAs disrupting gene regulation

E) B) and C)
F) All of the above

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For a successful emergence or re-emergence to occur, a pathogen must be introduced into a vulnerable population and have the ability to spread readily from person-to-person causing disease.

A) True
B) False

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Which of the following is not a normal portal of exit of an infectious disease?


A) Removal of blood
B) Urogenital tract and feces
C) Coughing and sneezing
D) Skin
E) All of these choices are normal exit portals.

F) C) and D)
G) A) and D)

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The Centers for Disease Control and Prevention assigns the most virulent microbes known to cause human disease to biosafety level 4.

A) True
B) False

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Which of the following is a mismatched term and description?


A) Secondary infection - infection spreads to several tissue sites
B) Mixed infection - several agents established at infection site
C) Acute infection - rapid onset of severe, short-lived symptoms
D) Local infection - pathogen remains at or near entry site
E) Toxemia - pathogen's toxins carried by the blood to target tissues

F) C) and D)
G) A) and B)

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