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Exam 5: Consolidating Ltp: Translation and Transcription

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Question 1

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Which observation(s) support(s) the idea that the fundamental consolidating event is the construction of an enlarged stable spine? (Select all that apply.)

A) Inhibiting NMDA receptors prevent LTP induction.
B) Preventing actin polymerization prevents LTP from enduring.
C) Preventing cofilin phosphorylation prevents LTP from enduring.
D) Inhibiting actin polymerization prevents the generation of LTP.
E) None of the above

F) B) and E)
G) None of the above

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Question 2

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Genomic signaling refers to processes initiated by synaptic events that lead to the transcription of new mRNA.

A) True
B) False

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Question 3

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What is a major feature of the genomic signaling hypothesis?

Calcium-induced calcium release occurs when calcium entering via NMDA receptors binds to RyRs on the endoplasmic reticulum.

Calcium-induced calcium release refers to extracellular calcium entering the cell.

Which statement(s) about IP3 is/are true? (Select all that apply.)

Why is emetine important?

According to the de novo protein synthesis (DNPS) hypothesis, long-lasting memories require that the learning experience generate new proteins.

What are plasticity products (PPs)?

Why does separating the dendrites from the soma provide evidence for local protein synthesis?

A strong stimulus initiates what two rounds of protein synthesis?

In the soma-to-nucleus cascade, repetitive action potentials are assumed to open voltage-dependent calcium channels.

_______ produced by the weak stimulus depends only on post-translation modifications and rearrangements of existing protein.

What is the major assumption in the soma-to-nucleus signaling model?

Why has anisomycin been used to study LTP?

The idea that synaptic activity leads to the transcription of new plasticity product needed to build long-lasting LTP is called the _______. (Select all that apply.)

Which can be found in the dendritic region? (Select all that apply.)

Describe the de novo protein synthesis hypothesis.

What two major findings illustrate the important role local protein synthesis plays in L-LTP?

Pretreatment with anisomycin, a protein synthesis inhibitor, prevents the strong stimulus from producing _______.