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Both Streptococcus pyogenes and Corynebacterium diphtheriae are highly pathogenic, and the disease symptomology can be very severe.Why is this?


A) Infants and children are the high-risk groups, and their mortality rate is higher than for other ages.
B) Both bacteria produce potent exotoxins.
C) They induce autoimmune states in the patients.
D) There are no antibiotics useful for diseases caused by these bacteria.

E) A) and B)
F) All of the above

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B

A diagnosis of tuberculosis involves a/an ______.


A) chest X ray
B) acid-fast stain of sputum
C) sputum culture
D) tuberculin skin test
E) All of the choices are correct.

F) B) and C)
G) A) and B)

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The causative organism of whooping cough is ______.


A) Bordetella pertussis
B) Streptococcus pneumoniae
C) Haemophilus influenzae
D) Streptococcus pyogenes
E) Cornyebacterium diphtheriae

F) C) and D)
G) All of the above

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Otitis media is commonly treated with broad spectrum antibiotics, although there is a lot of push-back or pressure against doing this.Why are these drugs given for this condition?


A) No other kinds of drugs and antibiotics can kill the bacteria causing otitis media other than the broad- spectrum class of drugs.
B) The narrow-spectrum drugs are very toxic as opposed to the rather benign broad-spectrum ones.
C) Otitis media is often caused by a variety of bacteria growing together in a biofilm, and the bacteria often exhibit different susceptibilities to drugs.
D) Fungi are the most common cause of otitis media, and the fungi do not respond well to the narrow-spectrum drugs.

E) All of the above
F) None of the above

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Which of the following does not describe S.pyogenes?


A) Group A streptococcus
B) Gram-positive
C) Forms endospores
D) Sensitive to bacitracin
E) Beta-hemolytic

F) A) and E)
G) A) and D)

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C

Which opportunist is the most frequent cause of life-threatening pneumonia in AIDS patients?


A) Cryptococcus neoformans
B) Candida albicans
C) Malassezia furfur
D) Pneumocystis (carinii) jiroveci

E) B) and C)
F) None of the above

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Pneumonias have different signs and symptoms depending on whether they are classified as CAP or HCAP.

A) True
B) False

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Annual influenza vaccinations are important for all individuals because


A) the virus is stable so once the vaccine is administered, protection from antibodies is lifelong.

B) the vaccine prevents secondary infections in individuals with influenza.

C) the oral-fecal transmission route makes it easy to pass to others.

D) the highly contagious nature of the virus means that transmission from a robust individual to those with a weaker immune system, such as the young or the elderly, is facilitated in crowded winter conditions

E) B) and D)
F) A) and B)

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Cold viruses are transmitted by _______.


A) droplet contact
B) indirect contact
C) direct contact
D) All of the choices are correct.

E) A) and D)
F) None of the above

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Diphtheria is considered to be an upper respiratory tract infection.However, it can have a very high mortality rate if not caught early and treated.Predict why this is so.


A) It makes a toxin that can be carried in blood and produce organ damage, particularly the heart.
B) It successfully hides from the immune system of the patient.
C) The patient cannot eat or drink and so basically starves to death.
D) The bacterium moves from the throat to the brain, causing strokes to occur.

E) None of the above
F) A) and D)

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Extrapulmonary TB is more common in


A) young children and immunosuppressed patients.
B) the elderly.
C) organ transplant patients.
D) AIDS patients.
E) All of the choices are correct.

F) C) and E)
G) A) and C)

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Virulence factors of S.pyogenes include


A) polysaccharides on the cell wall.
B) lipoteichoic acid.
C) spiky M proteins.
D) hyaluronic acid capsule.
E) All of the choices are correct.

F) A) and C)
G) B) and E)

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The trachea, due to its location in the body, is considered to be part of both the upper and lower respiratory tract.

A) True
B) False

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Severe acute respiratory syndrome (SARS)


A) causes high fever, pneumonia, and respiratory distress.
B) began with an initial outbreak in the United States and then spread to Canada and China.
C) is caused by the respiratory syncytial virus.
D) is classified as an opportunistic infection.

E) A) and D)
F) C) and D)

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Drug-resistant strains of Streptococcus pneumoniae are now treated with ______.


A) penicillin V
B) eryrthromycin
C) tetracyline
D) vancomycin
E) Ketek

F) A) and D)
G) A) and C)

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E

The difference between MDR-TB and XDR-TB is that


A) XDR-TB is predominantly seen in the USA whereas MDR-TB is common in India and China.
B) MDR-TB exhibits resistance to isoniazid and rifampin whereas XDR-TB strains are resistant to bedaquiline.
C) MDR-TB strains have a higher mortality rate than XDR-TB strains.
D) MDR-TB strains are classified as having resistance to two antibiotics, whereas XDR-TB strains are classified when they are resistant to four antibiotics.

E) C) and D)
F) A) and B)

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The vaccine for immunity to Haemophilus influenzae serotype b is ______.


A) DTaP
B) Pneumovax
C) MMR
D) Hib

E) All of the above
F) A) and B)

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Which of the following is not a virulence factor of Bordetella pertussis?


A) Endotoxin
B) Tracheal cytotoxin
C) M protein
D) Pertussis toxin
E) Filamentous hemagglutinin

F) A) and C)
G) D) and E)

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People who have received the BCG immunization will generally have a negative tuberculin skin test.

A) True
B) False

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People at greatest risk for pneumococcal infections include all the following except


A) the elderly.
B) those with underlying lung disease and viral infections.
C) patients without a spleen.
D) adolescents and young adults.
E) young infants.

F) A) and B)
G) None of the above

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