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In severe cases of Rocky Mountain spotted fever, the enlarged lesions of the rash can become necrotic and predispose the patient to gangrene of toes and fingertips.

A) True
B) False

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Epidemiologists classify diseases by their mortality rate (the percent of infected individuals who die from the disease) and by their communicability (how easy it is to transmit the disease) .Which of the following diseases of the cardiovascular system is mismatched with a description of its properties?


A) Ebola; high mortality rate and high communicability
B) Malaria; low mortality rate and high communicability
C) Plague; somewhat high mortality rate and low communicability
D) AIDS; high mortality rate and low communicability

E) C) and D)
F) B) and D)

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Which of the following statements regarding erhlichiosis is incorrect?


A) It often coinfects with Borrelia burgdorferi.
B) Treatment requires an extensive course of antibiotics, usually 3-6 weeks.
C) The disease vector is transmitted by Ixodes ticks.
D) Symptoms include fever, headache, and muscle pains.
E) The disease is diagnosed by PCR or indirect fluorescent antibody tests.

F) A) and B)
G) A) and C)

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Lyme disease involves


A) early symptoms of fever, headache, and stiff neck.
B) crippling polyarthritis, cardiovascular issues, and neurological problems.
C) people exposed to wooded or forested areas.
D) treatment with antimicrobials.
E) All of the choices are correct.

F) A) and C)
G) A) and B)

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Symptoms of infectious mononucleosis include


A) fever, severe diarrhea, pneumonitis, hepatitis, and retinitis.
B) sore throat, fever, cervical lymphadenopathy, and splenomegaly.
C) fever and pocks on skin.
D) vesicular lesions in oral mucosa.

E) None of the above
F) All of the above

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Despite the aggressive defense of the cardiovascular system by the immune system, some microbes can invade and establish an infection in the blood.From the following list of microbes and their virulence factors, identify the mismatch.


A) Bacillus anthracis produces antioxidants to combat lysosomes.
B) Coxiella burnetii produces an endospore-like structure.
C) Trypanosoma cruzi cloaks itself in host proteins to avoid immune recognition.
D) Borrelia burgdorferi changes its surface antigens to avoid immune recognition.

E) A) and B)
F) A) and D)

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Which of the following is not associated with sepsis?


A) Drop in blood pressure
B) Respiratory acidosis
C) Endotoxic shock
D) Parenteral or endogenous transfer
E) Fever and shaking chills

F) A) and D)
G) C) and E)

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Malaria may be prevented by


A) using bed nets sprayed with insecticide.
B) eliminating standing water.
C) taking prophylactic drugs.
D) using genetically engineered mosquitoes.
E) All of the choices are correct.

F) C) and D)
G) B) and D)

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Humans should be routinely vaccinated against Lyme disease.

A) True
B) False

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The causative agent in a case of sepsis can be isolated by


A) inoculating blood agar with a sample of the patient's blood.
B) performing a Kirby-Bauer assay on a sample of the patient's blood.
C) sending a blood sample to the CDC laboratories in Atlanta.
D) centrifugation of the blood to separate cells and plasma.

E) B) and C)
F) A) and D)

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Brucellosis is


A) treated with a 3-6 week course of antibiotics.
B) seen in patients as a fluctuating fever, with headache, muscle pain, and weakness.
C) diagnosed with serological testing of the patient's blood.
D) an occupational illness of people who work with animals.
E) All of the choices are correct.

F) A) and B)
G) None of the above

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The most common causative agent of acute endocarditis is ______.


A) Neisseria gonorrhoeae
B) Staphylococcus aureus
C) Epstein-Barr virus
D) Streptococcus pyogenes
E) Streptococcus pneumoniae

F) A) and E)
G) B) and E)

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The most important defense of the cardiovascular system against infection is ______.


A) lymphocytes in the blood
B) lymph nodes
C) the blood-brain barrier
D) fever

E) A) and B)
F) A) and C)

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For the following list of anti-HIV drugs and their mechanism of action, identify the mismatch.


A) Protease inhibitor; blocks the active site of the protease required for assembling new viral particles.
B) Integrase inhibitor; blocks the active site of the enzyme required to splice HIV DNA into the human genome
C) Reverse transcriptase inhibitor; blocks the active site of the enzyme required to convert viral RNA to DNA
D) AZT (azidothymidine) ; as an analog of thymidine, it is incorporated into viral RNA in place of thymidine

E) B) and C)
F) C) and D)

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The presence of viruses in the blood is called ______.


A) septicemia
B) fungemia
C) viremia
D) hemovirus

E) B) and D)
F) A) and B)

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Under normal healthy circumstances, the lymphatic system filters any microorganisms present.

A) True
B) False

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Which of the following statements is incorrect regarding malaria?


A) Trophozoites develop in red blood cells.
B) Gametocytes enter the mosquito as she draws a blood meal from a human.
C) Merozoites enter and multiply in liver cells.
D) The mosquito inoculates human blood with sporozoites.

E) A) and B)
F) A) and C)

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Which drug interferes with the action of an HIV enzyme needed for final assembly and maturation of the virus?


A) Fusion inhibitor
B) Reverse transcriptase inhibitor
C) Integrase inhibitor
D) Protease inhibitor

E) A) and C)
F) None of the above

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Which of the following statements is incorrect regarding patients with AIDS?


A) AIDS patients get repeated, life-threatening, opportunistic infections.
B) The highest number of AIDS cases worldwide is in the United States.
C) AIDS patients have an immunodeficiency.
D) AIDS patients have a CD4 T-cell titer below 200 cells/mm3 of blood.
E) AIDS patients can get unusual cancers and neurological disorders.

F) D) and E)
G) All of the above

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The causative agent of Lyme disease is ______.


A) Leptospira interrogans
B) Ixodes pacificus
C) Borrelia burgdorferi
D) Borrelia hermsii
E) Ixodes scapularis

F) A) and B)
G) C) and D)

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