Question 1

Which event occurs with the sensitizing dose of allergen?

Accepted Answer

A)  Degranulation
B)  Binding of allergen to adjacent IgE binding sites on mast cells and basophils
C)  Binding of IgE by the Fc region to mast cells and basophils
D)  Histamine acting on smooth muscle
E)  Prostaglandins causing vasodilation and increased vascular permeabilityF) None of the above
G) A) and C)

Question 2

In systemic lupus erythematosis (called lupus) , complexes of antibody and antigen form, and these immune complexes insert themselves into small blood vessels, joints, heart, and kidney, causing damage to the organ tissue.The course of the disease is unpredictable, with periods of illness alternating with remissions.How is lupus, a type III autoimmune disease, similar to the tuberculin reaction, a type IV hypersensitivity reaction?

Accepted Answer

A)  Both lupus and the tuberculin reaction utilize IgE in their mechanisms.
B)  Both lupus and the tuberculin reaction are immediate hypersensitivities, occurring within a few hours.
C)  Both lupus and the tuberculin reaction involve large amounts of antibody production.
D)  The mechanism of both lupus and the tuberculin reaction involve large amounts of inflammatory chemicals released into tissue.E) A) and B)
F) B) and C)

Question 3

The leukocyte histamine-release test (LHRT) measures the amount of histamine released from the patient's mast cells and eosinophils when exposed to a specific allergen.

Accepted Answer

A) True 
 B)False

Question 4

You have dermatitis triggered by a particular material in your socks.Your feet are covered with a really itchy rash, which has developed blisters over the last day or so.You had first worn them 2 to 3 days ago, and you did not launder them after buying them at the store.Finding some antihistamine medication in your bathroom cabinet, you decide to take it to relieve the itching rash.Which statement is true?

Accepted Answer

A)  The anti-histamine will have no effect because once a type I hypersensitivity kicks in, it will last for a few days.
B)  The rash will go away because the antihistamine neutralizes the histamine chemicals coming from mast cells in your skin.
C)  The anti-histamine will have no effect on the rash because histamine is not the chemical mediator in this hypersensitivity.
D)  The antihistamine will make the rash worse because it reacts with chemicals release by the lymphocytes in your skin, exacerbating the situation.E) B) and D)
F) C) and D)

Question 5

The initial encounter with an allergen is called the _____ dose.

Accepted Answer

A)  sensitizing
B)  provocative
C)  allergic
D)  hypersensitivity
E)  desensitizingF) B) and D)
G) A) and D)

Question 6

Severe combined immunodeficiencies (SCIDs)  are due to

Accepted Answer

A)  autoantibodies.
B)  failure of B-cell development and maturity.
C)  congenital absence or immaturity of the thymus gland.
D)  delayed hypersensitivity.
E)  a genetic defect in the development of both T cells and B cells.F) B) and E)
G) A) and E)

Question 7

Before a type II hypersensitivity can proceed, three immune components must be in place: complement, IgG, and IgM.

Accepted Answer

A) True 
 B)False

Question 8

The chemical mediator that causes prolonged bronchospasm, vascular permeability, and mucus secretion of asthmatic patients is ______.

Accepted Answer

A)  histamine
B)  leukotriene
C)  platelet-activating factor
D)  serotonin
E)  prostaglandinF) B) and D)
G) None of the above

Question 9

Large quantities of antibodies that react to the second entry of antigen and lead to formation of antigen-antibody complexes occurs in

Accepted Answer

A)  hemolytic disease of the newborn.
B)  anaphylaxis.
C)  serum sickness.
D)  delayed hypersensitivity.E) A) and D)
F) B) and D)

Question 10

The allergen in poison ivy plants is an oil called urushiol.

Accepted Answer

A) True 
 B)False

Question 11

Food allergies include gastrointestinal symptoms and often hives.

Accepted Answer

A) True 
 B)False

Question 12

Eczema is an autoimmune disorder.

Accepted Answer

A) True 
 B)False  False

Question 13

Transfusion of the wrong blood type can cause

Accepted Answer

A)  recipient antibody activation of the complement cascade to attack the RBCs.
B)  fever and anemia.
C)  systemic shock and kidney failure.
D)  massive hemolysis of the donor RBCs.
E)  All of the choices are correct.F) C) and E)
G) A) and E)

Question 14

The serum of a person with blood type A and Rh- will have the ability to make which of the following antibodies?

Accepted Answer

A)  Anti-B
B)  Anti-A
C)  Anti-A, anti-B, and anti-Rh
D)  Anti-A and anti-Rh
E)  Anti-B and anti-RhF) C) and D)
G) A) and B) E

Question 15

Many men make antibodies to sperm, resulting in destruction of sperm to the point of sterility.What would be the likely origin of this autoimmune disease?

Accepted Answer

A)  	T helper cells erroneously identify sperm cells as foreign invaders, triggering the T cytotoxic cells to start killing sperm.
B)  	Since sperm are not made until after puberty, the immune system cannot scan the antigens on the sperm for immune tolerance. After sperm are made and the immune system sees them, they are recognized as foreign.
C)  	Antigens on sperm cells are similar to antigens on a variety of bacteria like Streptococcus. After a strep throat caused by Streptococcus, the immune system produces antibodies to streptococcal antigens, which then cross react with sperm antigens and destroy them.
D)  	These antibodies are produced as a result of mutations in T lymphocytes, causing them to make large amounts of antibody.E) A) and B)
F) A) and C)

Question 16

Which type/s of hypersensitivities is IgG is involved with?

Accepted Answer

A)  Anaphylaxis
B)  Antibody-mediated
C)  Immune complex-mediated
D)  Both anaphylaxis and antibody-mediated.
E)  Both antibody-mediated and immune complex-mediated.F) A) and E)
G) A) and B)

Question 17

Predict why insect stings and medication injections more often provoke anaphylactic shock, as compared to other allergens found in food or in air.

Accepted Answer

A)  The allergens go directly into the blood in large amounts, compared to allergens entering the digestive tract or respiratory tract.
B)  Chemicals from insects cause a combination of antibody types to be produced, resulting in much larger amounts of total antibody.
C)  Histamine is overproduced as a result of injected chemicals.
D)  Chemicals injected as medications cause problems in immune response, resulting in a reduced immune coverage.E) None of the above
F) A) and B)

Question 18

Serum sickness and the Arthus reaction are both type III hypersensitivities, but they differ in that

Accepted Answer

A)  serum sickness is a systemic reaction to an injected therapy, whereas the Arthus reaction remains localized to the injection site.
B)  serum sickness is an infection in the blood serum, whereas the Arthus reaction is a swelling in the joints.
C)  serum sickness is vomiting and diarrhea in response to animal serum, whereas the Arthus reaction causes arthritis.
D)  serum sickness is a localized reaction to an injected therapy, whereas the Arthus reaction is systemic.E) B) and C)
F) A) and C)

Question 19

Immunopathology is defined as

Accepted Answer

A)  the study of immunodeficiencies.
B)  the study of AIDS.
C)  the study of autoimmune diseases.
D)  the study of immune imbalance, whether hyper- or hypoactivity.E) A) and D)
F) None of the above D

Question 20

During graft rejection, cytotoxic T cells of the recipient recognize and respond to foreign class I MHC receptors on the grafted cells.

Accepted Answer

A) True 
 B)False

Exam 16: Disorders in Immunity

Which event occurs with the sensitizing dose of allergen?

Correct Answer
verified

Correct Answer
verified

The leukocyte histamine-release test (LHRT) measures the amount of histamine released from the patient's mast cells and eosinophils when exposed to a specific allergen.

Correct Answer
verified

Correct Answer
verified

The initial encounter with an allergen is called the _____ dose.

Correct Answer
verified

Severe combined immunodeficiencies (SCIDs) are due to

Correct Answer
verified

Before a type II hypersensitivity can proceed, three immune components must be in place: complement, IgG, and IgM.

Correct Answer
verified

The chemical mediator that causes prolonged bronchospasm, vascular permeability, and mucus secretion of asthmatic patients is ______.

Correct Answer
verified

Large quantities of antibodies that react to the second entry of antigen and lead to formation of antigen-antibody complexes occurs in

Correct Answer
verified

The allergen in poison ivy plants is an oil called urushiol.

Correct Answer
verified

Food allergies include gastrointestinal symptoms and often hives.

Correct Answer
verified

Eczema is an autoimmune disorder.

Correct Answer
verified
False

Transfusion of the wrong blood type can cause

Correct Answer
verified

The serum of a person with blood type A and Rh^- will have the ability to make which of the following antibodies?

Correct Answer
verified
E

Many men make antibodies to sperm, resulting in destruction of sperm to the point of sterility.What would be the likely origin of this autoimmune disease?

Correct Answer
verified

Which type/s of hypersensitivities is IgG is involved with?

Correct Answer
verified

Predict why insect stings and medication injections more often provoke anaphylactic shock, as compared to other allergens found in food or in air.

Correct Answer
verified

Serum sickness and the Arthus reaction are both type III hypersensitivities, but they differ in that

Correct Answer
verified

Immunopathology is defined as

Correct Answer
verified
D

During graft rejection, cytotoxic T cells of the recipient recognize and respond to foreign class I MHC receptors on the grafted cells.

Correct Answer
verified

Exam 16: Disorders in Immunity

Which event occurs with the sensitizing dose of allergen?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

The leukocyte histamine-release test (LHRT) measures the amount of histamine released from the patient's mast cells and eosinophils when exposed to a specific allergen.

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

The initial encounter with an allergen is called the _____ dose.

Correct AnswerverifiedShow Answer

Severe combined immunodeficiencies (SCIDs) are due to

Correct AnswerverifiedShow Answer

Before a type II hypersensitivity can proceed, three immune components must be in place: complement, IgG, and IgM.

Correct AnswerverifiedShow Answer

The chemical mediator that causes prolonged bronchospasm, vascular permeability, and mucus secretion of asthmatic patients is ______.

Correct AnswerverifiedShow Answer

Large quantities of antibodies that react to the second entry of antigen and lead to formation of antigen-antibody complexes occurs in

Correct AnswerverifiedShow Answer

The allergen in poison ivy plants is an oil called urushiol.

Correct AnswerverifiedShow Answer

Food allergies include gastrointestinal symptoms and often hives.

Correct AnswerverifiedShow Answer

Eczema is an autoimmune disorder.

Correct AnswerverifiedFalse

Transfusion of the wrong blood type can cause

Correct AnswerverifiedShow Answer

The serum of a person with blood type A and Rh- will have the ability to make which of the following antibodies?

Correct AnswerverifiedE

Many men make antibodies to sperm, resulting in destruction of sperm to the point of sterility.What would be the likely origin of this autoimmune disease?

Correct AnswerverifiedShow Answer

Which type/s of hypersensitivities is IgG is involved with?

Correct AnswerverifiedShow Answer

Predict why insect stings and medication injections more often provoke anaphylactic shock, as compared to other allergens found in food or in air.

Correct AnswerverifiedShow Answer

Serum sickness and the Arthus reaction are both type III hypersensitivities, but they differ in that

Correct AnswerverifiedShow Answer

Immunopathology is defined as

Correct AnswerverifiedD

During graft rejection, cytotoxic T cells of the recipient recognize and respond to foreign class I MHC receptors on the grafted cells.

Correct AnswerverifiedShow Answer

Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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False

Correct Answer
verified

The serum of a person with blood type A and Rh^- will have the ability to make which of the following antibodies?

Correct Answer
verified
E

Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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D

Correct Answer
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