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Which of the following statements regarding Bacillus anthracis is incorrect?


A) A capsule and exotoxins are virulence factors.
B) Its reservoir includes grazing animals and soil.
C) It is a gram-positive bacillus.
D) It grows primarily under anaerobic conditions.
E) It is capable of forming endospores.

F) B) and E)
G) C) and D)

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The reservoir for the Lassa fever virus is the ______.


A) fruit bat
B) Aedes mosquito
C) deer tick
D) Anopheles mosquito
E) multimammate rat

F) D) and E)
G) A) and E)

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Which of the following statements is incorrect regarding patients with AIDS?


A) AIDS patients get repeated, life-threatening, opportunistic infections.
B) The highest number of AIDS cases worldwide is in the United States.
C) AIDS patients have an immunodeficiency.
D) AIDS patients have a CD4 T-cell titer below 200 cells/mm3 of blood.
E) AIDS patients can get unusual cancers and neurological disorders.

F) A) and E)
G) C) and E)

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Ehrlichiosis,Rocky Mountain Spotted Fever,dengue fever,and tularemia are all infectious diseases of the cardiovascular system.What feature do they have in common?


A) People with immune deficiencies are especially susceptible to these diseases.
B) They are all transmitted by arthropod vectors.
C) They are all endemic in the mountain states in the western U.S.
D) The causative agent of each of these diseases is a bacterium.

E) None of the above
F) A) and B)

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Retroviruses have all of the following characteristics except ______.


A) an envelope
B) integration into the host genome
C) glycoprotein spikes
D) reverse transcriptase
E) a DNA genome

F) A) and D)
G) A) and E)

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When bacteria flourish and grow in the blood stream,the condition is termed ______.


A) sepsis
B) fungemia
C) viremia
D) bactocarditis

E) A) and D)
F) A) and C)

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Cat scratch disease can be prevented by ______,


A) vaccination
B) avoiding unpasteurized milk
C) avoiding environments with ticks
D) animal control
E) promptly cleaning any scratch wound

F) C) and E)
G) B) and E)

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Under normal healthy circumstances,the lymphatic system filters any microorganisms present.

A) True
B) False

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True

For the following list of anti-HIV drugs and their mechanism of action,identify the mismatch.


A) Protease inhibitor; blocks the active site of the protease required for assembling new viral particles.
B) Integrase inhibitor; blocks the active site of the enzyme required to splice HIV DNA into the human genome
C) Reverse transcriptase inhibitor; blocks the active site of the enzyme required to convert viral RNA to DNA
D) AZT (azidothymidine) ; as an analog of thymidine, it is incorporated into viral RNA in place of thymidine

E) B) and C)
F) None of the above

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Your 49-year-old mother has just been diagnosed with subacute endocarditis with the following symptoms: fever,a rash,and early congestive heart failure.You wonder how this infection occurred,particularly since she appeared to be healthy before this.Which of the following questions for her physician is most pertinent to understanding the cause of this infection?


A) Is this infection related to menopause?
B) Could she have contracted this from a mosquito bite, since she does so much gardening?
C) Could she have AIDS?
D) Does she have an abnormal heart valve or a murmur?

E) None of the above
F) A) and B)

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D

Which type of hemorrhagic fever has been shown to respond to ribavirin?


A) Lassa fever
B) Marburg
C) Ebola
D) Rocky Mountain spotted fever

E) A) and B)
F) None of the above

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The white-footed mouse,deer,and deer ticks are important to maintaining the zoonotic transmission cycle associated with ______.


A) babesiosis
B) Q fever
C) plague
D) Lyme disease
E) Rocky Mountain spotted fever

F) A) and C)
G) A) and D)

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A common cardiovascular/lymphatic system disease in AIDS patients is ______.


A) brucellosis
B) Burkitt's lymphoma
C) cytomegalovirus
D) ehrlichiosis
E) acute endocarditis

F) C) and D)
G) A) and C)

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Erythema migrans,a bull's-eye rash,at the site of a tick bite is associated with ______.


A) Q fever
B) Rocky Mountain spotted fever
C) Lyme disease
D) plague
E) ehrlichiosis

F) A) and B)
G) A) and D)

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A frequent cancer that is seen in AIDS patients is ______.


A) Hodgkin's lymphoma
B) myeloma
C) Kaposi's sarcoma
D) melanoma
E) leukemia

F) A) and D)
G) A) and B)

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Plague is a quarantinable disease.

A) True
B) False

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Which drug interferes with the action of an HIV enzyme needed for final assembly and maturation of the virus?


A) Fusion inhibitor
B) Reverse transcriptase inhibitor
C) Integrase inhibitor
D) Protease inhibitor

E) All of the above
F) A) and D)

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An HIV-positive patient should be treated with a wide array of drugs because


A) the sooner s/he is treated with antivirals, the more likely it is that the virus will be eliminated from their blood.
B) s/he is susceptible to a variety of opportunistic infections and AIDS-defining illnesses.
C) most HIV-positive patients are also intravenous drug users and require chemotherapy for their addiction.
D) multiple antibiotics and antivirals should kill HIV and any resistant strains that might arise.

E) A) and B)
F) None of the above

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Which of the following statements concerning Rocky Mountain spotted fever is correct?


A) The causative bacterium is transmitted by Ixodes ticks.
B) Disease symptoms include fever, headache, and rash.
C) An infection rarely has complications beyond mild discomfort.
D) Infections are seen in highest numbers in the Rocky Mountains.

E) None of the above
F) A) and B)

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B

You just returned from a hiking/camping trip and are experiencing symptoms of an infection: high fever,swollen lymph nodes,and black-and-blue marks or hemorrhages under the skin.Your doctor asks if you have been in the four corners area of the U.S.(where the states of Arizona,Colorado,New Mexico,and Utah all meet) .What does the doctor suspect?


A) Since there are many mosquitoes in that area, you might have been infected with Plasmodium.
B) Hemorrhagic fever is often associated with bats in that region of the U.S.
C) Those four states have high rates of Chikungunya, which is what the doctor suspects that you have.
D) You might have picked up the plague bacterium from fleas that normally feed on rodents in that area.

E) A) and B)
F) A) and C)

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