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A soft callus forms during ___________.


A) endochondral ossification
B) intramembranous ossification
C) bone growth at the metaphysis
D) the remodeling of bone
E) the healing of a fracture

F) A) and D)
G) A) and C)

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Osteogenic cells are bone stem cells that differentiate into osteoblasts and osteoclasts.

A) True
B) False

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Which of the following is an inorganic component of the bone matrix?


A) Proteoglycans
B) Glycoproteins
C) Collagen
D) Hydroxyapatite
E) Glycosaminoglycans

F) None of the above
G) All of the above

Correct Answer

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Which of the following does not put women at risk for hypocalcemia?


A) Lactation
B) Pregnancy
C) Removal of the parathyroid glands
D) Removal of the thyroid gland
E) Lack of exposure to UV radiation

F) C) and E)
G) D) and E)

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The result of blood calcium and phosphate levels being too low for normal deposition is a softness of the bones called __________ in children and __________ in adults.


A) osteomalacia; rickets
B) rickets; osteomalacia
C) osteoporosis; osteomalacia
D) osteomyelitis; osteosarcoma
E) osteomyelitis; osteomalacia

F) D) and E)
G) All of the above

Correct Answer

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Mature bones are remodeled throughout life via a process known as __________.


A) intramembranous ossification
B) endochondral ossification
C) interstitial growth
D) appositional growth
E) metaphysical growth

F) A) and B)
G) A) and E)

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The plasma membrane of __________ have a ruffled border with many deep infoldings,whereas __________ have long,thin,fingerlike cytoplasmic processes.


A) osteoclasts; osteocytes
B) osteocytes; osteoclasts
C) osteoblasts; osteoclasts
D) osteoblasts; osteocytes
E) osteocytes; osteogenic cells

F) B) and C)
G) B) and D)

Correct Answer

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Blood Ca2+ deficiency stimulates __________ secretion,which leads to __________.


A) calcitonin; more urinary phosphate reabsorption
B) calcitriol; more urinary phosphate excretion
C) parathyroid hormone; increased osteoclast activity
D) growth hormone; increased osteoblast activity
E) thyroid hormone; less urinary calcium excretion

F) B) and D)
G) A) and C)

Correct Answer

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Bone-forming cells are called __________.


A) osteogenic (osteoprogenitor) cells
B) osteoblasts
C) osteoclasts
D) osteocytes
E) osteons

F) A) and B)
G) B) and D)

Correct Answer

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Which of the following exemplifies a positive feedback process happening in bone mineral deposition?


A) The first few crystals that form attract more calcium and phosphate.
B) Osteoblasts neutralize inhibitors that prevent bone resorption.
C) Osteoclasts secrete acid phosphatase that digests collagen.
D) Collagen is digested by enzymes and hydroxyapatite by hydrochloric acid.
E) Solubility product is reached in the tissue fluids.

F) B) and E)
G) B) and C)

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A radiograph (X-ray)of a child's hand will show epiphyseal lines.

A) True
B) False

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Bone protrudes through the skin in a fracture called __________.


A) complete
B) incomplete
C) closed
D) open
E) displaced

F) None of the above
G) D) and E)

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Intramembranous ossification produces the __________.


A) irregular bones of the vertebrae
B) flat bones of the skull
C) long bones of the limbs
D) short bones of the wrist
E) short bones of the ankle

F) C) and D)
G) A) and B)

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Which of the following is the correct sequence of events in the healing of a bone fracture?


A) Bone remodeling \rarr soft callus formation \rarr hard callus formation \rarr hematoma formation
B) Bone remodeling \rarr hard callus formation \rarr soft callus formation \rarr hematoma formation
C) Hematoma formation \rarr soft callus formation \rarr hard callus formation \rarr bone remodeling
D) Hematoma formation F \rarr hard callus formation \rarr soft callus formation \rarr bone remodeling
E) Soft callus formation \rarr hard callus formation \rarr hematoma formation \rarr bone remodeling

F) B) and E)
G) All of the above

Correct Answer

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The most common bone disease is __________.


A) osteomyelitis
B) osteoporosis
C) osteosarcoma
D) osteomalacia
E) rickets

F) D) and E)
G) B) and D)

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Bone elongation is a result of __________.


A) cartilage growth
B) muscle growth
C) osseous tissue growth
D) fibrous membrane addition
E) dense irregular connective tissue addition

F) A) and E)
G) B) and D)

Correct Answer

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Red bone marrow does not contain __________.


A) myeloid tissue
B) yellow bone marrow
C) hemopoietic tissue
D) white blood cells
E) red blood cells

F) A) and B)
G) A) and C)

Correct Answer

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If a thyroid tumor secreted an excessive amount of calcitonin,we would expect ___________.


A) an elevated level of osteoclast activity
B) an elevated level of osteoblast activity
C) a reduced rate of endochondral ossification
D) a rise in blood calcium concentration
E) increasingly brittle bones

F) A) and B)
G) A) and E)

Correct Answer

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Patches of fibrocartilage formed in the healing of a fracture are called __________,whereas the bony collar formed around the fracture is called __________.


A) fracture hematoma; granulation tissue
B) granulation tissue; soft callus
C) fracture hematoma; hard callus
D) granulation tissue; hard callus
E) soft callus; hard callus

F) All of the above
G) B) and C)

Correct Answer

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Intramembranous ossification is common in children,whereas endochondral ossification is typical in young adults.

A) True
B) False

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